ArticleFrontiers in pharmacology2021
Ligustilide Prevents Radiation Enteritis by Targeting Gch1/BH
Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05138887 (Clinical Professor), which is not on this map. Cited by 7 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Professor
Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- The Evolving Research Landscape of Radiation Enteritis Prevention and Management: A Data-Driven Analysis.Journal of inflammation research · 2026Article
- Gross-tumor-volume segment-anything model for medical 2D images integrating gross tumor volume-minimal feature integration technology for lung cancer segmentation.Quantitative imaging in medicine and surgery · 2026Article
- D-S-Net: an efficient dual-stage strategy for high-precision segmentation of gross tumor volumes in lung cancer CT images.BMC cancer · 2025Article
- RAU-Net for precise lung cancer GTV segmentation in radiation therapy planning.Scientific reports · 2025Article
- Dual-channel hypergraph convolutional network for predicting herb-disease associations.Briefings in bioinformatics · 2024Article
- Automatic segmentation of the gross target volume in radiotherapy for lung cancer using transresSEUnet 2.5D Network.Journal of translational medicine · 2022Article
- Research progress on the mechanism of radiation enteritis.Frontiers in oncology · 2022Review
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a high incidence of radiation enteritis (RE) after abdominal radiotherapy. The occurrence of RE seriously affects the treatment and quality of life of patients; however, its pathogenesis is complex and there are no effective drugs for its prevention or treatment. Intestinal ischemia plays an important role in the occurrence of enteritis. Previous studies have shown that targeting GTP-cyclohydrolase 1 (Gch1) to improve intestinal ischemia could be a new strategy to prevent and treat RE. A high content of the naturally occurring phthalide derivative ligustilide (LIG) has been found in the plant drug Rhizoma Ligustici Chuanxiong for the treatment of cardiovascular diseases. The purpose of this study was to evaluate the protective effects of LIG on RE. Ionizing radiation (IR) rat and endothelial cell models were used to observe and record rat body weights and stool morphologies, measure intestinal blood perfusion by laser Doppler blood flow imaging, determine the diastolic functions of mesenteric arteries, detect the levels of Gch1/BH
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