Evidence map›Paper›PMID 33967355›Full record

ArticleInternational journal of polymeric materials2021

Theranostic applications of stimulus-responsive systems based on carbon dots.

Behrad Ghiasi, Golnaz Mehdipour, Nooshin Safari, Hamidreza Behboudi, Mohadeseh Hashemi, Meisam Omidi, Yahya Sefidbakht, Amir Yadegari, Michael R Hamblin

Abstract read
In one paragraph

Article in International journal of polymeric materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Behrad GhiasiProtein Research Center, Shahid Beheshti University, Tehran, Iran.ORCID 0000-0002-5207-6272
Golnaz MehdipourProtein Research Center, Shahid Beheshti University, Tehran, Iran.
Nooshin SafariProtein Research Center, Shahid Beheshti University, Tehran, Iran.
Hamidreza BehboudiProtein Research Center, Shahid Beheshti University, Tehran, Iran.
Mohadeseh HashemiProtein Research Center, Shahid Beheshti University, Tehran, Iran.
Meisam OmidiSchool of Dentistry, Marquette University, Milwaukee, WI, USA.
Yahya SefidbakhtProtein Research Center, Shahid Beheshti University, Tehran, Iran.
Amir YadegariSchool of Dentistry, Marquette University, Milwaukee, WI, USA.
Michael R HamblinMassachusetts General Hospital, Wellman Center for Photomedicine, Boston, MA, USA.ORCID 0000-0001-6431-4605

Funding

Photodynamic Therapy of Localized InfectionsR01AI050875 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2003 to 2017
$4.8M
Synergistic Photodynamic Therapy for Catherer-Associated Urinary Tract InfectionsR21AI121700 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2016 to 2017
$462k
NIAID NIH HHS R01 AI050875NIAID NIH HHS R21 AI121700
6 · The paper itself

Abstract

Over recent years, many different nanoparticle-based drug delivery systems (NDDSs) have been developed. Recently the development of stimulus-responsive NDDSs has come into sharper focus. Carbon dots (CDs) possess outstanding features such as useful optical properties, good biocompatibility, and the ability for easy surface modification. Appropriate surface modification can allow these NDDSs to respond to various chemical or physical stimuli that are characteristic of their target cells or tissue (frequently malignant cells or tumors). The present review covers recent developments of CDs in NDDSs with a particular focus on internal stimulus response capability that allows simultaneous imaging and therapeutic delivery (theranostics). Relevant stimuli associated with tumor cells and tumors include pH levels, redox potential, and different enzymatic activities can be used to activate the CDs at the desired sites.

Indexed as

Carbon dotsdrug deliverynanoparticlesstimulus responsivetheranosticstumor targeting

Identifiers

PMID33967355
PMCPMC8101985

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.