Evidence map›Paper›PMID 33967331›Full record

ArticleJournal of food science and technology2021

Effects on weaned male Wistar rats after 104, 197, and 288 days of chronic consumption of nutritive and non-nutritive additives in water.

Samuel Mendoza-Pérez, Mauricia Betzabeth Guzmán-Gómez, Rolando Salvador García-Gómez, Guillermo Ordaz-Nava, María Isabel Gracia-Mora, Lucía Macías-Rosales, Héctor Morales-Rico, Gerardo Salas-Garrido, María Del Carmen Durán-Domínguez-de-Bazúa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of food science and technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Re-evaluation of acesulfame K (E 950) as food additive.EFSA journal. European Food Safety Authority · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Samuel Mendoza-PérezLaboratories of Environmental Chemical Engineering and Chemistry, Complex E, Building E-3 Food and Environmental Chemistry, Laboratories 301, 302, 303, Department of Chemical Engineering, Faculty of Chemistry (Universidad Nacional Autónoma de México, Facultad de Química, Departamento de Ingeniería Química, Laboratorios de Ingeniería Química Ambiental y de Química Ambiental, Conjunto E, Edificio E-3 Alimentos y Química Ambiental, Laboratorios 301, 302, 303, in Spanish), UNAM, Circuito de la Investigación Científica s/n, Ciudad Universitaria, 04510 Mexico City, Mexico.
Mauricia Betzabeth Guzmán-GómezLaboratories of Environmental Chemical Engineering and Chemistry, Complex E, Building E-3 Food and Environmental Chemistry, Laboratories 301, 302, 303, Department of Chemical Engineering, Faculty of Chemistry (Universidad Nacional Autónoma de México, Facultad de Química, Departamento de Ingeniería Química, Laboratorios de Ingeniería Química Ambiental y de Química Ambiental, Conjunto E, Edificio E-3 Alimentos y Química Ambiental, Laboratorios 301, 302, 303, in Spanish), UNAM, Circuito de la Investigación Científica s/n, Ciudad Universitaria, 04510 Mexico City, Mexico.
Rolando Salvador García-GómezLaboratories of Environmental Chemical Engineering and Chemistry, Complex E, Building E-3 Food and Environmental Chemistry, Laboratories 301, 302, 303, Department of Chemical Engineering, Faculty of Chemistry (Universidad Nacional Autónoma de México, Facultad de Química, Departamento de Ingeniería Química, Laboratorios de Ingeniería Química Ambiental y de Química Ambiental, Conjunto E, Edificio E-3 Alimentos y Química Ambiental, Laboratorios 301, 302, 303, in Spanish), UNAM, Circuito de la Investigación Científica s/n, Ciudad Universitaria, 04510 Mexico City, Mexico.
Guillermo Ordaz-NavaINCMNSZ, Department of Nutrition Physiology, Molecular Nutrition Area (Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", INCMNSZ, Departamento de Fisiología de la Nutrición, Área de Nutrición Molecular, in Spanish), National Institute of Medical Sciences and Nutrition "Salvador Zubirán", 14030 Mexico City, Mexico.
María Isabel Gracia-MoraAnimal Experimentation Unit, Faculty of Chemistry, UNEXA, Complex E (Universidad Nacional Autónoma de México, Facultad de Química, Unidad de Experimentación Animal, UNEXA, Conjunto E, in Spanish), UNAM, Circuito de la Investigación Científica s/n, Ciudad Universitaria, 04510 Mexico City, Mexico.
Lucía Macías-RosalesAnimal Experimentation Unit, Faculty of Chemistry, UNEXA, Complex E (Universidad Nacional Autónoma de México, Facultad de Química, Unidad de Experimentación Animal, UNEXA, Conjunto E, in Spanish), UNAM, Circuito de la Investigación Científica s/n, Ciudad Universitaria, 04510 Mexico City, Mexico.
Héctor Morales-RicoAnimal Experimentation Unit, Faculty of Chemistry, UNEXA, Complex E (Universidad Nacional Autónoma de México, Facultad de Química, Unidad de Experimentación Animal, UNEXA, Conjunto E, in Spanish), UNAM, Circuito de la Investigación Científica s/n, Ciudad Universitaria, 04510 Mexico City, Mexico.
Gerardo Salas-GarridoDepartment of Pathology, Faculty of Veterinary Medicine and Zootechnics (Universidad Nacional Autónoma de México, Facultad de Medicina Veterinaria y Zootecnia, Departamento de Patología, in Spanish), UNAM, Circuito de la Investigación Científica s/n, Ciudad Universitaria, 04510 Mexico City, Mexico.
María Del Carmen Durán-Domínguez-de-BazúaLaboratories of Environmental Chemical Engineering and Chemistry, Complex E, Building E-3 Food and Environmental Chemistry, Laboratories 301, 302, 303, Department of Chemical Engineering, Faculty of Chemistry (Universidad Nacional Autónoma de México, Facultad de Química, Departamento de Ingeniería Química, Laboratorios de Ingeniería Química Ambiental y de Química Ambiental, Conjunto E, Edificio E-3 Alimentos y Química Ambiental, Laboratorios 301, 302, 303, in Spanish), UNAM, Circuito de la Investigación Científica s/n, Ciudad Universitaria, 04510 Mexico City, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abstractIt has been suggested that the consumption of artificial sweeteners is related to greater body mass gain and diverse metabolic alterations. In this study, the effect of chronic consumption of nutritive sweeteners (fructose 7% and sucrose 10%) and non-nutritive or low-calorie sweeteners (acesulfame 0.015%, aspartame 0.3%, aspartame:acesulfame mixture 0.04%, saccharin 0.3%, and sucralose 0.19%), in drinking water, as well as a control group with no sweeteners, was evaluated. Body mass gain and glucose, insulin, triglycerides, and total cholesterol levels in blood were the parameters considered. For this purpose, 120 weaned male Wistar rats of the HsdHan:WIST line were used, 15 per group in first stage, then 10 and 5 per group for 2nd and 3rd stages, respectively. Body mass gain, food intake, and beverage consumption were daily quantified. After 104, 197, and 288 days of experimentation the concentrations of glucose, triglycerides, cholesterol, and insulin were determined. Only in the first stage there were significant differences in the body mass gain. In the three stages there were significant differences in the patterns of beverage intake and food consumption. The trend was the same in all 3 stages: rats drank more in the groups of drinks sweetened with nutritive sweeteners and ate more in the groups that drank non-nutritive artificial sweeteners. Regarding the biochemical profile, no sweetener either nutritive or non-nutritive caused that the serum levels of glucose, triglycerides, and cholesterol were at pathological levels. It is concluded that the sweeteners by themselves can modify certain biochemical parameters but not at a pathological level. Furthermore, by themselves they are not capable of triggering excess of body mass or obesity in the early and medium stages of life when consumed together with a balanced diet. GRAPHIC ABSTRACT:

Indexed as

Body mass gainInsulinNon-nutritive sweetenersSerum glucoseTotal cholesterolTriglycerides

Identifiers

PMID33967331
PMCPMC8076370

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.