Evidence map›Paper›PMID 33967276›Full record

ArticleBone marrow transplantation2021

Salvage HLA-haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide for graft failure in non-malignant disorders.

Michael H Albert, Mehtap Sirin, Manfred Hoenig, Fabian Hauck, Catharina Schuetz, Rajat Bhattacharyya, Polina Stepensky, Elad Jacoby, Tayfun Güngör, Rita Beier and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Bone marrow transplantation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  3. Review
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 4 countries.

Michael H Albert *Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Munich, Germany. malbert@med.lmu.de.ORCID http://orcid.org/0000-0001-9143-3263
Mehtap Sirin *Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.
Manfred HoenigDepartment of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.ORCID http://orcid.org/0000-0001-9165-1690
Fabian HauckDepartment of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Munich, Germany.
Catharina SchuetzDepartment of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Rajat BhattacharyyaHaematology Oncology Service, Department of Paediatric subspecialties, KK Women's and Children's Hospital, Bukit Timah, Singapore.
Polina StepenskyFaculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Elad JacobyDivision of Pediatric Hematology Oncology and BMT, The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.ORCID http://orcid.org/0000-0003-1411-8942
Tayfun GüngörDepartment of Hematology/Oncology/Immunology, Gene-therapy, and Stem Cell Transplantation, University Children's Hospital Zürich - Eleonore Foundation & Children's Research Center (CRC), Zürich, Switzerland.ORCID http://orcid.org/0000-0002-3261-1186
Rita BeierDepartment of Pediatric Hematology and Oncology, University Duisburg-Essen, Essen, Germany.
Ansgar SchulzDepartment of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.ORCID http://orcid.org/0000-0002-7798-7996
University Hospital Ulm · DELMU Klinikum · DEHebrew University of Jerusalem · ILKK Women's and Children's Hospital · SGMedizinische Hochschule Hannover · DETel Aviv University · ILUniversity Children's Hospital Zurich · CHUniversity Hospital Carl Gustav Carus · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Graft failure requires urgent salvage HSCT, but there is no universally accepted approach for this situation. We investigated T-cell replete haploidentical HSCT with post-transplantation cyclophosphamide following serotherapy-based, radiation-free, reduced intensity conditioning in children with non-malignant disorders who had rejected their primary graft. Twelve patients with primary or secondary graft failure received T-cell replete bone marrow grafts from haploidentical donors and post-transplantation cyclophosphamide. The recommended conditioning regimen comprised rituximab 375 mg/m

Indexed as

Graft vs Host DiseaseHematopoietic Stem Cell TransplantationCyclophosphamideHumansRetrospective StudiesTransplantation ConditioningCyclophosphamide

Identifiers

PMID33967276
PMCPMC8106764
OpenAlexW3161004002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.