Observational studyCritical care medicine2021
Functional Outcomes and Their Association With Physical Performance in Mechanically Ventilated Coronavirus Disease 2019 Survivors at 3 Months Following Hospital Discharge: A Cohort Study.
Observational study in Critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Functional Recovery of Adults Following Acute COVID-19: A Systematic Review and Meta-Analysis.Physical therapy · 2025Pooled it
- Persistent impairments in muscle function and symptom burden in post-COVID syndrome: a prospective longitudinal study.Journal of translational medicine · 2026Observational
- New and persistent psychoactive medication use in intensive care unit survivors with COVID-19: a multicentre population-based cohort study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2026Article
- Creatine supplementation on fatigue related to post-COVID-19 condition-fatigue study: a randomized controlled trial.Frontiers in nutrition · 2026Article
- The Maastricht Intensive Care COVID Cohort: A Critical Appraisal of the Predefined Research Questions.Critical care explorations · 2025Article
- A Pilot Case-Control Study of Muscle and Bone Health Status in Patients Who Have Recovered From COVID-19 Infection.Cureus · 2024Article
- Pulmonary Rehabilitation Program Is an Effective Treatment Approach for Post-COVID-19 Syndrome Patients.Journal of clinical medicine · 2024Article
- Outcome Measures to Evaluate Functional Recovery in Survivors of Respiratory Failure: A Scoping Review.CHEST critical care · 2024Article
- Mental health status among COVID-19 patients survivors of critical illness in Saudi Arabia: A 6-month follow-up questionnaire study.World journal of clinical cases · 2024Article
- Effects of acute phase intensive electrical muscle stimulation in COVID-19 patients requiring invasive mechanical ventilation: an observational case-control study.Scientific reports · 2024Observational
- Effects of Aerobic Exercise Therapy through Nordic Walking Program in Lactate Concentrations, Fatigue and Quality-of-Life in Patients with Long-COVID Syndrome: A Non-Randomized Parallel Controlled Trial.Journal of clinical medicine · 2024Article
- Association between muscle quality index and pulmonary function in post-COVID-19 subjects.BMC pulmonary medicine · 2023Article
- Instruments to assess post-intensive care syndrome assessment: a scoping review and modified Delphi method study.Critical care (London, England) · 2023Article
- Chest CT opportunistic biomarkers for phenotyping high-risk COVID-19 patients: a retrospective multicentre study.European radiology · 2023Article
- Longitudinal Changes in Physical Function and Their Impact on Health Outcomes in COVID-19 Patients.Nutrients · 2023Article
- Physical function and mental health trajectories in COVID-19 patients following invasive mechanical ventilation: a prospective observational study.Scientific reports · 2023Observational
- Study protocol for TARGET protein: The effect of augmented administration of enteral protein to critically ill adults on clinical outcomes: A cluster randomised, cross-sectional, double cross-over, clinical trial.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2023Article
- Functional status and quality of life in post-COVID-19 patients two to three weeks after hospitalization: A cross-sectional study.Health science reports · 2023Article
- Post-intensive care syndrome and pulmonary fibrosis in patients surviving ARDS-pneumonia of COVID-19 and non-COVID-19 etiologies.Scientific reports · 2023Article
- Musculoskeletal involvement: COVID-19 and post COVID 19.Turkish journal of physical medicine and rehabilitation · 2023Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe performed a comprehensive health assessment in mechanically ventilated coronavirus disease 2019 survivors to assess the impact of respiratory and skeletal muscle injury sustained during ICU stay on physical performance at 3 months following hospital discharge.
designPreregistered prospective observational cohort study.
settingUniversity hospital ICU. PATIENTS: All mechanically ventilated coronavirus disease 2019 patients admitted to our ICU during the first European pandemic wave. MEASUREMENTS AND MAIN
resultsAt 3 months after hospital discharge, 46 survivors underwent a comprehensive physical assessment (6-min walking distance, Medical Research Council sum score and handgrip strength), a full pulmonary function test, and a chest CT scan which was used to analyze skeletal muscle architecture. In addition, patient-reported outcomes measures were collected. Physical performance assessed by 6-minute walking distance was below 80% of predicted in 48% of patients. Patients with impaired physical performance had more muscle weakness (Medical Research Council sum score 53 [51-56] vs 59 [56-60]; p < 0.001), lower lung diffusing capacity (54% [44-66%] vs 68% of predicted [61-72% of predicted]; p = 0.002), and higher intermuscular adipose tissue area (p = 0.037). Reduced lung diffusing capacity and increased intermuscular adipose tissue were independently associated with physical performance.
conclusionsPhysical disability is common at 3 months in severe coronavirus disease 2019 survivors. Lung diffusing capacity and intermuscular adipose tissue assessed on CT were independently associated with walking distance, suggesting a key role for pulmonary function and muscle quality in functional disability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.