Evidence map›Paper›PMID 33967176›Full record

Trial reportNeurologia medico-chirurgica2021

Focused Ultrasound Thalamotomy for Tremor-dominant Parkinson's Disease: A Prospective 1-year Follow-up Study.

Kazuaki Yamamoto, Hisashi Ito, Shigeru Fukutake, Takashi Odo, Tetsumasa Kamei, Toshio Yamaguchi, Takaomi Taira

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurologia medico-chirurgica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Surgical Treatment of Tremor Syndromes: A Guide to the Clinician.Movement disorders clinical practice · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. High Intensity Focused Ultrasound - Longitudinal Data on Efficacy and Safety.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025
    Review
  10. Article
  11. Clinical neurophysiology in the treatment of movement disorders: IFCN handbook chapter.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kazuaki YamamotoDepartment of Neurosurgery, Tokyo Women's Medical University.
Hisashi ItoDepartment of Neurology, Shonan Fujisawa Tokushukai Hospital.
Shigeru FukutakeDepartment of Neurology, Shonan Fujisawa Tokushukai Hospital.
Takashi OdoDepartment of Neurology, Shonan Fujisawa Tokushukai Hospital.
Tetsumasa KameiDepartment of Neurology, Shonan Fujisawa Tokushukai Hospital.
Toshio YamaguchiResearch Institute of Diagnostic Imaging, Shin-Yurigaoka General Hospital.
Takaomi TairaDepartment of Neurosurgery, Tokyo Women's Medical University.
Yokufukai Hospital · JPTokyo Women's Medical University · JPMidorigaoka Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcranial magnetic resonance (MR)-guided focused ultrasound (FUS) therapy is an emerging and minimally invasive treatment for movement disorders. There are limited reports on its long-term outcomes for tremor-dominant Parkinson's disease (TDPD). We aimed to investigate the 1-year outcomes of ventralis intermedius (VIM) thalamotomy with FUS in patients with TDPD. Patients with medication-refractory TDPD were enrolled and underwent unilateral VIM-FUS thalamotomy. Neurologists specializing in movement disorders evaluated the tremor symptoms and disability using Parts A, B, and C of the Clinical Rating Scale for Tremor (CRST) at baseline and at 1, 3, and 12 months. In all, 11 patients (mean age: 71.6 years) were included in the analysis. Of these, five were men. The median (interquartile range) improvement from baseline in hand tremor score, the total score, and functional disability score were 87.9% (70.5-100.0), 65.3% (55.7-87.7), and 66.7% (15.5-85.1), respectively, at 12 months postoperatively. This prospective study demonstrated an improvement in the tremor and disability of patients at 12 months after unilateral VIM-FUS thalamotomy for TDPD. In addition, there were no serious persistent adverse events. Our results indicate that VIM-FUS thalamotomy can be safely and effectively used to treat patients with TDPD. A randomized controlled trial with a larger cohort and long blinded period would help investigate the recurrence, adverse effects, placebo effects, and longer efficacy of this technique.

Indexed as

Essential TremorParkinson DiseaseAgedFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleProspective StudiesThalamusTreatment OutcomeTremormagnetic resonance imagingthalamotomytranscranial focused ultrasoundtremor-dominant Parkinson’s diseaseventralis intermedius nucleus

Identifiers

PMID33967176
PMCPMC8280323
OpenAlexW3162533499

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.