ArticleJournal of Alzheimer's disease : JAD2021
Hypertension and Hypercholesterolemia Modify Dementia Risk in Relation to APOEɛ4 Status.
Article in Journal of Alzheimer's disease : JAD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Article
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- Abnormal Internal Carotid Artery Kinking in a Cadaver: Morphogenesis and a Potential Link to Alzheimer's Disease.Cureus · 2025Article
- Factors associated with dementia among older people in Malaysia: Findings from National Health and Morbidity Survey.Australasian journal on ageing · 2025Article
- Mechanisms of glutamate metabolic function and dysfunction in vascular dementia.Neuroprotection (Chichester, England) · 2024Review
- Influence of daily life and health profile in subtle cognitive decline of women residing in Spanish religious communities: DeCo religious orders study.Frontiers in public health · 2024Observational
- Diabetes and hypertension are related to amyloid-beta burden in the population-based Rotterdam Study.Brain : a journal of neurology · 2023Article
- Arrhythmia and other modifiable risk factors in incident dementia and MCI among elderly individuals with low educational levels in Taiwan.Frontiers in aging neuroscience · 2022Article
- Association between Particulate Matter Pollution Concentration and Hospital Admissions for Hypertension in Ganzhou, China.International journal of hypertension · 2022Article
- Pharmacists' Knowledge of Factors Associated with Dementia: The A-to-Z Dementia Knowledge List.International journal of environmental research and public health · 2021Article
- Sociodemographic and clinical profile from the Brazilian very old 90+ study (BRAVO-90+).Journal of Alzheimer's disease reportsArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThere is significant interest in understanding the role of modifiable vascular risk factors contributing to dementia risk across age groups.
objectiveRisk of dementia onset was assessed in relation to vascular risk factors of hypertension and hypercholesterolemia among cognitively normal APOEɛ4 carriers and non-carriers.
methodsIn a sample of prospectively characterized longitudinal cohort from the National Alzheimer's Coordinating Center database, 9,349 participants met criteria for normal cognition at baseline, had a CDR-Global (CDR-G) score of zero, and had concomitant data on APOEɛ4 status and medical co-morbidities including histories of hypertension and hypercholesterolemia. Multivariable Cox proportional hazards models adjusted for well-known potential confounders were used to compare dementia onset among APOEɛ4 carriers and non-carriers by young (≤65 years) and old (> 65 year) age groups.
results519 participants converted to dementia within an average follow up of 5.97 years. Among older APOEɛ4 carriers, hypercholesterolemia was related to lower risk of dementia (HR (95% CI), 0.68 (0.49-0.94), p = 0.02). Among older APOEɛ4 non-carriers, hypertension was related to higher risk of dementia (HR (95% CI), 1.44 (1.13-1.82), p = 0.003). These results were corroborated among a subset with autopsy data characterizing underlying neuropathology. Among younger participants, vascular risk factors did not impact dementia risk, likely from a lower frequency of vascular and Alzheimer's as etiologies of dementia among this cohort.
conclusionA history of hypercholesterolemia related to a lower risk of dementia among older APOEɛ4 carriers, while hypertension related to a higher risk of dementia among older APOEɛ4 non-carriers.
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