Evidence map›Paper›PMID 33966673›Full record

ArticleInternational psychogeriatrics2022

Wisdom and fluid intelligence are dissociable in healthy older adults.

Cutter A Lindbergh, Heather Romero-Kornblum, Sophia Weiner-Light, J Clayton Young, Corrina Fonseca, Michelle You, Amy Wolf, Adam M Staffaroni, Rebecca Daly, Dilip V Jeste and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International psychogeriatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Cutter A LindberghMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Heather Romero-KornblumMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Sophia Weiner-LightMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
J Clayton YoungMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Corrina FonsecaMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Michelle YouMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Amy WolfMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Adam M StaffaroniMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Rebecca DalyDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Dilip V JesteDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Joel H KramerMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Winston ChiongMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
Hillblom Aging Network

Funding

Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Gil Dan Rabinovici · 2019 to 2026
$36.9M
Mechanisms of Executive Decline in Normal AgingR01AG032289 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kaitlin B Casaletto, JOEL H KRAMER · 2009 to 2026
$8.3M
Decision-Making in Genetic FTDR01AG022983 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHIONG, WINSTON · 2004 to 2021
$6.0M
Decision-making abilities in Alzheimer's Disease and related dementias: From clinical standards to decision neuroscienceR01AG058817 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHIONG, WINSTON · 2018 to 2022
$3.4M
Effects of chronic inflammation on brain structure and functionR01AG048234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRAMER, JOEL H · 2015 to 2019
$3.2M
Optimizing Clinical Trial Endpoints in Frontotemporal DementiaK23AG061253 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STAFFARONI, ADAM MARK · 2019 to 2023
$946k
NIA NIH HHS K23 AG061253NIA NIH HHS P30 AG062422NIA NIH HHS R01 AG022983NIA NIH HHS R01 AG032289NIA NIH HHS R01 AG048234NIA NIH HHS R01 AG058817
6 · The paper itself

Abstract

objectivesThe relationship between wisdom and fluid intelligence (Gf) is poorly understood, particularly in older adults. We empirically tested the magnitude of the correlation between wisdom and Gf to help determine the extent of overlap between these two constructs.

designCross-sectional study with preregistered hypotheses and well-powered analytic plan (https://osf.io/h3pjx).

settingMemory and Aging Center at the University of California San Francisco, located in the USA.

participants141 healthy older adults (mean age = 76 years; 56% female). MEASUREMENTS: Wisdom was quantified using a well-validated self-report-based scale (San Diego Wisdom Scale or SD-WISE). Gf was assessed via composite measures of processing speed (Gf-PS) and executive functioning (Gf-EF). The relationships of SD-WISE scores to Gf-PS and Gf-EF were tested in bivariate correlational analyses and multiple regression models adjusted for demographics (age, sex, and education). Exploratory analyses evaluated the relationships between SD-WISE and age, episodic memory performance, and dorsolateral and ventromedial prefrontal cortical volumes on magnetic resonance imaging.

resultsWisdom showed a small, positive association with Gf-EF (r = 0.181 [95% CI 0.016, 0.336], p = .031), which was reduced to nonsignificance upon controlling for demographics, and no association with Gf-PS (r = 0.019 [95% CI -0.179, 0.216], p = .854). Wisdom demonstrated a small, negative correlation with age (r = -0.197 [95% CI -0.351, -0.033], p = .019), but was not significantly related to episodic memory or prefrontal volumes.

conclusionsOur findings indicate that most of the variance in wisdom (>95%) is unaccounted for by Gf. The independence of wisdom from cognitive functions that reliably show age-associated declines suggests that it may hold unique potential to bolster decision-making, interpersonal functioning, and other everyday activities in older adults.

Indexed as

IntelligenceMemory, EpisodicAgedAgingCognitionCross-Sectional StudiesExecutive FunctionFemaleHumansMaleagingcognitionexecutive functioningneuroimagingprocessing speed

Identifiers

PMID33966673
PMCPMC8578582

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.