Evidence map›Paper›PMID 33966609›Full record

ArticleCell cycle (Georgetown, Tex.)2021

Genome profiling of mismatch repair genes in eight types of tumors.

Siqi Wang, Gefei Guan, Cunyi Zou, Qing Guo, Wen Cheng, Shuai Shen, Fang Dong, Anhua Wu, Guang Li, Chen Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Siqi WangDepartment of Radiation Oncology, The First Hospital of China Medical University, Shenyang, China.
Gefei GuanDepartment of Neurosurgery, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Cunyi ZouDepartment of Neurosurgery, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Qing GuoDepartment of Neurosurgery, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Wen ChengDepartment of Neurosurgery, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Shuai ShenDepartment of Neurosurgery, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Fang DongDepartment of Pathology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Anhua WuDepartment of Neurosurgery, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Guang LiDepartment of Radiation Oncology, The First Hospital of China Medical University, Shenyang, China.
Chen ZhuDepartment of Neurosurgery, The First Hospital of China Medical University, Shenyang, Liaoning, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mismatch repair (MMR) plays an important role in the occurrence and development of tumors. At present, it is widely believed that MMR is a protective mechanism of tumors that plays a critical role in the progresses of cancer. In this study, 34 genes related to MMR selected from Gene Ontology (GO) database were scored by single sample Gene sets enrichment analysis (ssGSEA), and eight cancers were screened from 23 TCGA solid cancers to investigate the clinical significance of MMR score. MMR had different effects on the prognosis of the eight tumors, with a protective effect in three cancers and functioning as a risk factor in the remaining five cancers. We used unsupervised clustering to divide the patients into four clusters. We found that the immune and metabolic status of the four clusters were extremely different, among which cluster1 had the lowest tumor purity and the most complex microenvironment; this may explain its poor prognosis and immunotherapy effect. In summary, MMR scores can improve the predictive ability and provide effective guidance for immunotherapy in individual type of tumors.

Indexed as

Biomarkers, TumorDatabases, GeneticDNA Mismatch RepairGenomeHumansNeoplasmsSequence Analysis, RNATranscriptomeTumor MicroenvironmentBiomarkers, Tumorimmune microenvironmentmismatch repairPan cancer

Identifiers

PMID33966609
PMCPMC8208120

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.