Observational studyStroke2021
Ischemic Stroke, Inflammation, and Endotheliopathy in COVID-19 Patients.
Open access · bronzeAbstract readObservational Study
In one paragraph
Observational study in Stroke, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Identifying factors contributing to increased susceptibility to COVID-19 risk: a systematic review of Mendelian randomization studies.International journal of epidemiology · 2022Pooled it
- Decoding long COVID-associated cardiovascular dysfunction: Mechanisms, models, and new approach methodologies.Journal of molecular and cellular cardiology · 2025Review
- Sex Disparities Among Lithuanian Ischemic Stroke Patients According to Laboratory Findings; Comorbidities, Including COVID-19; Acute In-Hospital Complications; and Outcomes.Medicina (Kaunas, Lithuania) · 2025Article
- Neuropsychiatric Manifestations of Long COVID-19: A Narrative Review of Clinical Aspects and Therapeutic Approaches.Life (Basel, Switzerland) · 2025Review
- The stroke meta-metric, Defect-Free Care, was maintained year-over-year within the Florida stroke registry during the COVID-19 pandemic.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2025Article
- Acute and long-term effects of COVID-19 on brain and mental health: A narrative review.Brain, behavior, and immunity · 2025Review
- Neurological, psychological, psychosocial complications of long-COVID and their management.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- Article
- Epidemiology, pathogenesis, and management of Coronavirus disease 2019-associated stroke.Frontiers of medicine · 2023Review
- Update on Anticoagulation Strategies in Patients with ECMO-A Narrative Review.Journal of clinical medicine · 2023Review
- Article
- Thrombosis and bleeding in patients with COVID-19 requiring extracorporeal membrane oxygenation: a systematic review and meta-analysis.Research and practice in thrombosis and haemostasis · 2023Review
- Comparison of C-reactive protein with distinct hyperinflammatory biomarkers in association with COVID-19 severity, mortality and SARS-CoV-2 variants.Frontiers in immunology · 2023Article
- Chronic Endothelial Dysfunction after COVID-19 Infection Shown by Transcranial Color-Coded Doppler: A Cross-Sectional Study.Biomedicines · 2022Article
- Understanding COVID-19-associated coagulopathy.Nature reviews. Immunology · 2022Review
- Article
- Risk Stratification Models for Stroke in Patients Hospitalized with COVID-19 Infection.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2022Article
- Vasculopathy in COVID-19.Blood · 2022Review
- Long COVID and neuropsychiatric manifestations (Review).Experimental and therapeutic medicine · 2022Review
- Therapeutic Trends of Cerebrovascular Disease during the COVID-19 Pandemic and Future Perspectives.Journal of stroke · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 2 countries.
Lindsay S McAlpineDepartment of Neurology (L.S.M., A.S.Z., I.M., P.C., P.L., A.S.J., D.N., J.S., K.N.S., S.S., R.S., L.H.S.), Yale University School of Medicine, New Haven, CT.
Adeel S ZubairDepartment of Neurology (L.S.M., A.S.Z., I.M., P.C., P.L., A.S.J., D.N., J.S., K.N.S., S.S., R.S., L.H.S.), Yale University School of Medicine, New Haven, CT.
Ilavarasy MaranDepartment of Neurology (L.S.M., A.S.Z., I.M., P.C., P.L., A.S.J., D.N., J.S., K.N.S., S.S., R.S., L.H.S.), Yale University School of Medicine, New Haven, CT.
Pola ChojeckaDepartment of Neurology (L.S.M., A.S.Z., I.M., P.C., P.L., A.S.J., D.N., J.S., K.N.S., S.S., R.S., L.H.S.), Yale University School of Medicine, New Haven, CT.
Paul LlevaDepartment of Neurology (L.S.M., A.S.Z., I.M., P.C., P.L., A.S.J., D.N., J.S., K.N.S., S.S., R.S., L.H.S.), Yale University School of Medicine, New Haven, CT.
Adam S JasneDepartment of Neurology (L.S.M., A.S.Z., I.M., P.C., P.L., A.S.J., D.N., J.S., K.N.S., S.S., R.S., L.H.S.), Yale University School of Medicine, New Haven, CT.
Dhasakumar NavaratnamDepartment of Neurology (L.S.M., A.S.Z., I.M., P.C., P.L., A.S.J., D.N., J.S., K.N.S., S.S., R.S., L.H.S.), Yale University School of Medicine, New Haven, CT.
Charles MatoukDepartment of Neurosurgery (C.M.), Yale University School of Medicine, New Haven, CT.
Joseph SchindlerDepartment of Neurology (L.S.M., A.S.Z., I.M., P.C., P.L., A.S.J., D.N., J.S., K.N.S., S.S., R.S., L.H.S.), Yale University School of Medicine, New Haven, CT.
Kevin N ShethDepartment of Neurology (L.S.M., A.S.Z., I.M., P.C., P.L., A.S.J., D.N., J.S., K.N.S., S.S., R.S., L.H.S.), Yale University School of Medicine, New Haven, CT.
Hyung ChunDepartment of Internal Medicine, Section of Cardiovascular Medicine (H.C.), Yale University School of Medicine, New Haven, CT.
Alfred I LeeDepartment of Internal Medicine, Section of Hematology (A.I.L.), Yale University School of Medicine, New Haven, CT.
Serena SpudichDepartment of Neurology (L.S.M., A.S.Z., I.M., P.C., P.L., A.S.J., D.N., J.S., K.N.S., S.S., R.S., L.H.S.), Yale University School of Medicine, New Haven, CT.
Richa Sharma *Department of Neurology (L.S.M., A.S.Z., I.M., P.C., P.L., A.S.J., D.N., J.S., K.N.S., S.S., R.S., L.H.S.), Yale University School of Medicine, New Haven, CT.
Lauren H Sansing *Department of Neurology (L.S.M., A.S.Z., I.M., P.C., P.L., A.S.J., D.N., J.S., K.N.S., S.S., R.S., L.H.S.), Yale University School of Medicine, New Haven, CT.
Norwegian Womens Public Health Association · NOYale University · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MAnticoagulation in ICH Survivors for Prevention and Recovery (ASPIRE)U01NS106513 · NINDS · YALE UNIVERSITY · PI Hooman Kamel, Kevin Navin Sheth · 2019 to 2026
$20.6MThe Recovery in Stroke Using PAP (RISE UP) StudyR01NR018335 · NINR · YALE UNIVERSITY · PI REDEKER, NANCY S, SHETH, KEVIN NAVIN · 2019 to 2023
$3.4MSouthern New England Partnership In Stroke Research, Innovation and Treatment (SPIRIT)U24NS107215 · NINDS · YALE UNIVERSITY · PI MARK Jay ALBERTS, Karen L Furie · 2018 to 2026
$3.0MDynamic Neuroimmune Profiling in Patients with Acute Intracerebral HemorrhageR01NS097728 · NINDS · YALE UNIVERSITY · PI SANSING, LAUREN H · 2016 to 2020
$2.8MImproved glyburide therapy via acid- triggered release functional nanoparticles and therapeutic imagingR01NS110721 · NINDS · YALE UNIVERSITY · PI SHETH, KEVIN NAVIN, ZHOU, JIANGBING · 2019 to 2023
$1.9MEfferocytosis and the resolution of inflammation after intracerebral hemorrhageR01NS095993 · NINDS · YALE UNIVERSITY · PI SANSING, LAUREN H · 2016 to 2020
$1.8MYale Clinical Site: Investigations For Improved Neurological Treatments at Yale (INFINITY)U24NS107136 · NINDS · YALE UNIVERSITY · PI SHETH, KEVIN NAVIN, SPUDICH, SERENA S · 2018 to 2022
$1.7MYale site for Stroke Preclinical Assessment Network (SPAN) for Acute NeuroprotectionU01NS113445 · NINDS · YALE UNIVERSITY · PI SANSING, LAUREN H · 2019 to 2021
$1.2MIntensive Blood Pressure Reduction in Deep Intracerebral HemorrhageR03NS112859 · NINDS · YALE UNIVERSITY · PI FALCONE, GUIDO JOSE, SHETH, KEVIN NAVIN · 2019 to 2020
$84kAmerican Heart Association-American Stroke Association 17CSA33550004American Heart Association-American Stroke Association 20SRG35540018American Heart Association-American Stroke Association EIA34770133NCATS NIH HHS UL1 TR001863NIH HHS U01 NS106513-02S1NINDS NIH HHS R01 NS095993NINDS NIH HHS R01 NS097728NINDS NIH HHS R01 NS110721NINDS NIH HHS R03 NS112859NINDS NIH HHS U01 NS106513NINDS NIH HHS U01 NS113445NINDS NIH HHS U24 NS107136NINDS NIH HHS U24 NS107215NINR NIH HHS R01 NR018335
Abstract
[Figure: see text].
Indexed as
AgedAged, 80 and overBrain IschemiaCohort StudiesCOVID-19Endothelium, VascularHumansInflammationInflammation MediatorsIschemic StrokeMiddle AgedRetrospective StudiesInflammation Mediatorscoronaviruscytokinesembolic strokeischemic strokevon Willebrand Factor
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.