Evidence map›Paper›PMID 33966451›Full record

ArticleHypertension (Dallas, Tex. : 1979)2021

Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans.

Vienna E Brunt, Abigail G Casso, Rachel A Gioscia-Ryan, Zachary J Sapinsley, Brian P Ziemba, Zachary S Clayton, Amy E Bazzoni, Nicholas S VanDongen, James J Richey, David A Hutton and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 2 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.

  1. Pooled it
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  7. Biologics for cardiovascular diseases: from bench to bedside.Signal transduction and targeted therapy · 2026
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  16. Relationship of TMAO levels with vascular function in patients with hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Article
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Vienna E BruntFrom the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.).
Abigail G CassoFrom the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.).
Rachel A Gioscia-RyanFrom the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.).
Zachary J SapinsleyFrom the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.).
Brian P ZiembaFrom the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.).
Zachary S ClaytonFrom the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.).
Amy E BazzoniFrom the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.).
Nicholas S VanDongenFrom the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.).
James J RicheyFrom the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.).
David A HuttonFrom the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.).
Melanie C ZiglerFrom the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.).
Andrew P NeilsonDepartment of Food Science and Technology (A.P.N.).
Kevin P DavyDepartment of Human Nutrition, Foods, and Exercise (K.P.D.), Virginia Tech, Blacksburg.
Douglas R SealsFrom the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., A.G.C., R.A.G.-R., Z.J.S., B.P.Z., Z.S.C., A.E.B., N.S.V., J.J.R., D.A.H., M.C.Z., D.R.S.).
Anna Needs Neuroblastoma Answers · USNorth Carolina State University · USUniversity of Colorado Boulder · USVirginia Tech · US

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Translational Studies of Age-Associated Arterial Dysfunction, Western Diet and Aerobic Exercise: Role of the Gut MicrobiomeR01HL134887 · NHLBI · UNIVERSITY OF COLORADO · PI SEALS, DOUGLAS R · 2017 to 2020
$3.1M
Vascular Consequences of Ultra-Processed Foods in Middle-Aged AdultsR21AG075930 · NIA · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI DAVY, KEVIN P · 2022 to 2023
$455k
Gut Microbiota, Trimethylamine N-Oxide, and Endothelial Dysfunction in Middle-Aged AdultsR21AG058931 · NIA · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI DAVY, KEVIN P · 2018 to 2019
$434k
Translational studies of gut-derived trimethylamine N-oxide: a target for prevention and treatment of age-associated vascular endothelial dysfunctionF32HL140875 · NHLBI · UNIVERSITY OF COLORADO · PI BRUNT, VIENNA E · 2018 to 2019
$89k
NCATS NIH HHS UL1 TR002535NHLBI NIH HHS F32 HL140875NHLBI NIH HHS R01 HL134887NIA NIH HHS R21 AG058931NIA NIH HHS R21 AG075930
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

AdolescentAdultAgedAge FactorsAgingAnimalsAortaBlood PressureFemaleHumansMaleMethylaminesMiceMiddle AgedPulse Wave AnalysisVascular StiffnessMethylaminestrimethyloxamineadvanced glycation end productsarterial stiffnessgut microbiotapulse wave velocity

Identifiers

PMID33966451
PMCPMC8266738
OpenAlexW3161117129

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.