ArticleDaru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences2021
Polyherbal combination for wound healing: Matricaria chamomilla L. and Punica granatum L.
Article in Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Evaluating efficacy, safety, and innovation in skin care applications of essential oils: a systematic review.Frontiers in medicine · 2025Pooled it
- A critical overview of challenging roles of medicinal plants in improvement of wound healing technology.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024Pooled it
- Efficacy and safety of Compound Chamomile-Lidocaine Gel for postoperative wound management after pediatric circumcision: a multicenter randomized controlled trial.Translational andrology and urology · 2026Article
- The Role of Essential Oils in Sports Recovery and Performance.Molecules (Basel, Switzerland) · 2025Review
- Wound Healing Traits ofArchives of Razi Institute · 2025Article
- Review
- Medicinal plants used for cutaneous wound healing in Uganda; ethnomedicinal reports and pharmacological evidences.Heliyon · 2024Review
- Essential Oil ofClinical, cosmetic and investigational dermatology · 2024Article
- Plant Extracts as Skin Care and Therapeutic Agents.International journal of molecular sciences · 2023Review
- Medicinal Plants of the Flora of Kazakhstan Used in the Treatment of Skin Diseases.Molecules (Basel, Switzerland) · 2023Review
- Comparative analysis of the phenolic contents and antioxidant activities of different parts of two pomegranate (Frontiers in plant science · 2023Article
- Polymeric/Dextran Wafer Dressings as Promising Long-Acting Delivery Systems for Curcumin Topical Delivery and Enhancing Wound Healing in Male Wistar Albino Rats.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Wound Healing and Anti-Inflammatory Effects of a Newly Developed Ointment Containing Jujube Leaves Extract.Life (Basel, Switzerland) · 2022Article
- Determination of Chemical Compounds and Investigation of Biological Properties ofMolecules (Basel, Switzerland) · 2022Article
- Current Knowledge on Interactions of Plant Materials Traditionally Used in Skin Diseases in Poland and Ukraine with Human Skin Microbiota.International journal of molecular sciences · 2022Review
- Chamomile (Life (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPunica granatum L. (pomegranate) with astringent activities and Matricaria chamomilla L. (chamomile) with anti-inflammatory and antioxidant properties are natural remedies used for various skin disorders, including wound healing.
objectivesThis study was conducted to evaluate the individual and combined wound healing activity of the methanol extracts of pomegranate and chamomile flowers.
methodsAfter preparing the menthol fraction of pomegranate and chamomile flowers, the content of total phenols, total tannins, and total flavonoids of fractions was measured. For standardization of pomegranate and chamomile fractions, Gallic acid and apigenin-7-O-glucoside contents of them were determined using high-performance liquid chromatography (HPLC). Moreover, their antioxidant activities were examined using DPPH and FRAP tests. The antimicrobial assay was performed against Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa. Three different concentrations of methanol fraction of each plant and one combination dose of fractions were investigated for their wound healing activities in an excision wound model on the rats' dorsum. Finally, histopathological studies were done at the end of the experiment.
resultsPhytochemical examinations showed high amounts of phenolic compounds in pomegranate flowers, while chamomile flower fractions contained a high amount of total flavonoids. Both fractions, especially pomegranate, had potent antioxidant activity. The best results for wound closure were observed 7 days after wound induction. All treated groups exhibited superior wound contraction compared to their placebo at all measurement times. The combined form of pomegranate and chamomile had better wound healing properties compared to a single therapy, especially on time earlier to wound induction.
conclusionThis study represented high antioxidant and wound healing activities for methanol fraction of pomegranate and chamomile flowers, which could be related to their high content of phytochemicals. In comparison with single herb treatment, the combined form of these two fractions in lower concentrations accelerated wound closure.
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