Evidence map›Paper›PMID 33966243›Full record

ArticleAdvances in experimental medicine and biology2021

Probe Design Optimization for Time-Domain NIROT "Pioneer" System for Imaging the Oxygenation of the Preterm Brain.

A Di Costanzo-Mata, J Jiang, S Lindner, C Zhang, E Charbon, M Wolf, A Kalyanov

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In one paragraph

Article in Advances in experimental medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

A Di Costanzo-MataBiomedical Optics Research Laboratory (BORL), Department of Neonatology, University of Zurich and University Hospital Zurich, Zurich, Switzerland. aldo.dicostanzomata@usz.ch.
J JiangBiomedical Optics Research Laboratory (BORL), Department of Neonatology, University of Zurich and University Hospital Zurich, Zurich, Switzerland.
S LindnerBiomedical Optics Research Laboratory (BORL), Department of Neonatology, University of Zurich and University Hospital Zurich, Zurich, Switzerland.
C ZhangApplied Quantum Architectures, Delft University of Technology, Delft, the Netherlands.
E CharbonAdvanced Quantum Architecture (AQUA), Laboratory, School of Engineering, EPFL Lausanne, Lausanne, Switzerland.
M WolfBiomedical Optics Research Laboratory (BORL), Department of Neonatology, University of Zurich and University Hospital Zurich, Zurich, Switzerland.
A KalyanovBiomedical Optics Research Laboratory (BORL), Department of Neonatology, University of Zurich and University Hospital Zurich, Zurich, Switzerland.
University Hospital of Zurich · CHÉcole Polytechnique Fédérale de Lausanne · CHDelft University of Technology · NLUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In preterm infants, there is a risk of life-lasting impairments due to hemorrhagic/ischemic lesions. Our time-domain (TD) near-infrared optical tomography (NIROT) system "Pioneer" aims at detecting both disorders with high spatial resolution. Successfully tested on phantoms, "Pioneer" entered the phase of improvements and enhancements. The current probe (A-probe) was adapted for an optoacoustics instrument. A new probe (B-probe) optimized for TD measurements is required. Our aim is to determine the optimal arrangement of light sources in the B-probe to increase the sensitivity and the resolution of Pioneer and to improve the ability of the system to detect both ischemia and hemorrhage. To do this, we simulated TD-NIROT signals in NIRFAST, a MATLAB-based package used to model near-infrared light propagation through tissue. We used 16 × 16 detector array, with ~2.2 mm distance between the detectors. Light sources were arranged around the field of view (FoV). We performed forward simulations of light propagation through a "homogeneous case" (HC) tissue (μ'

Indexed as

BrainInfant, PrematureDiagnostic ImagingHumansInfant, NewbornPhantoms, ImagingSpectrum AnalysisNear-infrared optical tomography (NIROT)Time-domain imagingTime-domain NIROTTime-domain simulationsTissue oxygenation

Identifiers

PMID33966243
OpenAlexW3163127409

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.