Evidence map›Paper›PMID 33966240›Full record

ArticleAdvances in experimental medicine and biology2021

In Phantom Validation of Time-Domain Near-Infrared Optical Tomography Pioneer for Imaging Brain Hypoxia and Hemorrhage.

J Jiang, S Lindner, A Di Costanzo-Mata, C Zhang, E Charbon, M Wolf, A Kalyanov

Open access · greenAbstract read
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In one paragraph

Article in Advances in experimental medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

J JiangBiomedical Optics Research Laboratory (BORL), Department of Neonatology, University of Zurich and University Hospital Zurich, Zurich, Switzerland.
S LindnerBiomedical Optics Research Laboratory (BORL), Department of Neonatology, University of Zurich and University Hospital Zurich, Zurich, Switzerland.
A Di Costanzo-MataBiomedical Optics Research Laboratory (BORL), Department of Neonatology, University of Zurich and University Hospital Zurich, Zurich, Switzerland.
C ZhangApplied Quantum Architectures, Delft University of Technology, Delft, the Netherlands.
E CharbonAdvanced Quantum Architecture (AQUA) laboratory, School of Engineering, EPFL Lausanne, Lausanne, Switzerland.
M WolfBiomedical Optics Research Laboratory (BORL), Department of Neonatology, University of Zurich and University Hospital Zurich, Zurich, Switzerland.
A KalyanovBiomedical Optics Research Laboratory (BORL), Department of Neonatology, University of Zurich and University Hospital Zurich, Zurich, Switzerland. alexander.kalyanov@usz.ch.
University Hospital of Zurich · CHDelft University of Technology · NLÉcole Polytechnique Fédérale de Lausanne · CHUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The neonatal brain is a vulnerable organ, and lesions due to hemorrhage and/or ischemia occur frequently in preterm neonates. Even though neuroprotective therapies exist, there is no tool available to detect the ischemic lesions. To address this problem, we have recently designed and built the new time-domain near-infrared optical tomography (TD NIROT) system - Pioneer. Here we present the results of a phantom study of the system performance. We used silicone phantoms to mimic risky situations for brain lesions: hemorrhage and hypoxia. Employing Pioneer, we were able to reconstruct accurately both position and optical properties of these inhomogeneities.

Indexed as

Hypoxia, BrainTomography, OpticalHemorrhageHumansHypoxiaInfant, NewbornPhantoms, ImagingDiffuse optical tomographyPreterm brain imagingTime-domain near-infrared optical tomography (TD NITOR)Tissue optical properties reconstructionTissue oxygenation

Identifiers

PMID33966240
OpenAlexW3161824664

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.