Evidence map›Paper›PMID 33966217›Full record

ArticleAdvances in experimental medicine and biology2021

Mechanisms of Sound-Induced Opening of the Blood-Brain Barrier.

O Semyachkina-Glushkovskaya, D Bragin, O Bragina, Y Yang, A Abdurashitov, A Esmat, A Khorovodov, A Terskov, M Klimova, I Agranovich and 5 more

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PubMed Full text at PMC Publisher
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Article in Advances in experimental medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

O Semyachkina-GlushkovskayaSaratov State University, Saratov, Russia.
D BraginLovelace Biomedical Research Institute, Albuquerque, NM, USA.
O BraginaLovelace Biomedical Research Institute, Albuquerque, NM, USA.
Y YangUniversity of New Mexico, College of Pharmacy, Albuquerque, NM, USA.
A AbdurashitovSaratov State University, Saratov, Russia.
A EsmatSaratov State University, Saratov, Russia.
A KhorovodovSaratov State University, Saratov, Russia.
A TerskovSaratov State University, Saratov, Russia.
M KlimovaSaratov State University, Saratov, Russia.
I AgranovichSaratov State University, Saratov, Russia.
I BlokhinaSaratov State University, Saratov, Russia.
A ShirokovInstitute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, Saratov, Russia.
N NavolokinSaratov State Medical University, Saratov, Russia.
V TuchinSaratov State University, Saratov, Russia.
J KurthsSaratov State University, Saratov, Russia.

Funding

University of New Mexico (UNM) Center for Brain Recovery and RepairP20GM109089 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI SHUTTLEWORTH, CLAUDE W · 2015 to 2024
$22.7M
Brain Injury Treatment by Modulation of Hemodynamics With Blood Soluble Drag Reducing MoleculesR01NS112808 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BRAGIN, DENIS E. · 2019 to 2023
$2.1M
NIGMS NIH HHS P20 GM109089NINDS NIH HHS R01 NS112808
6 · The paper itself

Abstract

The blood-brain barrier (BBB) poses a significant challenge for drug delivery to the brain. The limitations of our knowledge about the nature of BBB explain the slow progress in the therapy of brain diseases and absence of methods for drug delivery to the brain in clinical practice. Here, we show that the BBB opens for high-molecular-weight compounds after exposure to loud sound (100 dB 370 Hz) in rats. The role of stress induced by loud sound and the systemic and molecular mechanisms behind it are discussed in the framework of the BBB. This opens an informative platform for novel fundamental knowledge about the nature of BBB and for the development of a noninvasive brain drug delivery technology.

Indexed as

Blood-Brain BarrierBrainAnimalsBiological TransportDrug Delivery SystemsRatsSoundBlood-brain barrierCerebral blood oxygen saturationLoud soundMechanismsMeningeal lymphatic clearance

Identifiers

PMID33966217
PMCPMC9131853

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.