Evidence map›Paper›PMID 33966191›Full record

ArticleAdvances in experimental medicine and biology2021

Systems Biology Model of Cerebral Oxygen Delivery and Metabolism During Therapeutic Hypothermia: Application to the Piglet Model.

Joshua Russell-Buckland, P Kaynezhad, S Mitra, G Bale, C Bauer, I Lingam, C Meehan, A Avdic-Belltheus, K Martinello, A Bainbridge and 2 more

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In one paragraph

Article in Advances in experimental medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.1field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Joshua Russell-BucklandDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK. j.russell-buckland.15@ucl.ac.uk.
P KaynezhadDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK.
S MitraInstitute for Women's Health, University College London, London, UK.
G BaleDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK.
C BauerDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK.
I LingamInstitute for Women's Health, University College London, London, UK.
C MeehanInstitute for Women's Health, University College London, London, UK.
A Avdic-BelltheusInstitute for Women's Health, University College London, London, UK.
K MartinelloInstitute for Women's Health, University College London, London, UK.
A BainbridgeDepartment of Medical Physics and Biomedical Engineering, University College London Hospital, London, UK.
N J RobertsonInstitute for Women's Health, University College London, London, UK.
I TachtsidisDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK.
University College London · GBLondon Women's Clinic · GBUniversity College Hospital · GB

Funding

Medical Research Council MR/S003134/1
6 · The paper itself

Abstract

Hypoxic ischaemic encephalopathy (HIE) is a significant cause of death and disability. Therapeutic hypothermia (TH) is the only available standard of treatment, but 45-55% of cases still result in death or neurodevelopmental disability following TH. This work has focussed on developing a new brain tissue physiology and biochemistry systems biology model that includes temperature effects, as well as a Bayesian framework for analysis of model parameter estimation. Through this, we can simulate the effects of temperature on brain tissue oxygen delivery and metabolism, as well as analyse clinical and experimental data to identify mechanisms to explain differing behaviour and outcome. Presented here is an application of the model to data from two piglets treated with TH following hypoxic-ischaemic injury showing different responses and outcome following treatment. We identify the main mechanism for this difference as the Q

Indexed as

Hypothermia, InducedHypoxia-Ischemia, BrainAnimalsBayes TheoremOxygenSwineSystems BiologyOxygenBrainBroadband NIRSHypothermiaPigletSystems biology

Identifiers

PMID33966191
OpenAlexW3160387629

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.