SynthesisJournal of thrombosis and thrombolysis2021
Association of serum uric acid with mortality and cardiovascular outcomes in patients with hypertension: a meta-analysis.
Synthesis in Journal of thrombosis and thrombolysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Pooled it
- Effects of Allisartan on Uric Acid, Left Atrial, Left Ventricular, and Artery Stiffness in Mild-to-Moderate Essential Hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2025Trial
- Article
- Correlation between serum uric acid levels and target organ damage in apparently healthy subjects with newly diagnosed Grade I/Grade II essential hypertension: An observational cross-sectional study.Journal of family medicine and primary care · 2026Article
- Association between the uric acid-to-albumin ratio and risk of all-cause mortality in centenarians: a prospective cohort study.Frontiers in nutrition · 2026Article
- Predicting Left Ventricular Ejection Fraction Recovery After Percutaneous Coronary Intervention in Patients With Chronic Coronary Syndrome by Using Interpretable Machine Learning Models: Retrospective Study.JMIR medical informatics · 2025Article
- Identifying pathways to cardiovascular mortality by causal graphical models and mediation analysis among hypertensive patients: insights from a prospective study.Journal of translational medicine · 2025Article
- Article
- Home blood pressure-lowering effect of esaxerenone versus trichlormethiazide for uncontrolled hypertension: a predefined subanalysis of the EXCITE-HT randomized controlled trial by basal calcium channel blocker versus angiotensin receptor blocker.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Sex- and country-specific associations of hyperuricemia and inflammation with vascular aging across populations with diverse cardiovascular risks.Frontiers in medicine · 2025Article
- A Cohort Study on the Correlation Between Serum Uric Acid Trajectory and New-Onset Hypertension Based on Longitudinal Health Examination Data in Henan Area.Journal of inflammation research · 2024Article
- A Systematic Review and Meta-Analysis of the Association between Uric Acid and Allantoin and Rheumatoid Arthritis.Antioxidants (Basel, Switzerland) · 2023Review
- The relation between uric acid level and blood pressure values among patients hospitalized in a department of internal medicine.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2023Article
- Article
- Serum uric acid: A risk factor for right ventricular dysfunction and prognosis in heart failure with preserved ejection fraction.Frontiers in endocrinology · 2023Article
- Increased serum uric acid level is associated with better outcome after endovascular treatment for acute ischemic stroke-a prospective cohort study.Annals of translational medicine · 2022Article
- Relationship between serum uric acid and hypertension in patients with primary Sjögren's syndrome: A retrospective cohort study.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Serum Uric Acid and Hyperuricemia Associate with Coronary Artery Disease among Postmenopausal Women.Reviews in cardiovascular medicine · 2022Article
- Moderate increase of serum uric acid within a normal range is associated with improved cognitive function in a non-normotensive population: A nationally representative cohort study.Frontiers in aging neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies on the association of uric acid with mortality and cardiovascular outcomes in patients with hypertension have produced contradictory results. The objective of this meta-analysis was to evaluate the prognostic utility of uric acid in hypertensive patients. We comprehensively searched PubMed and Embase databases (until July 31, 2020) to identify eligible studies that reported the association of uric acid with mortality and cardiovascular outcomes in hypertensive patients. Outcome measures included cardiovascular or all-cause mortality, coronary artery disease (CAD), stroke, and major adverse cardiovascular events (MACEs). Eleven eligible studies of 49,800 hypertensive patients were identified. For patients with the highest than those with reference lower group of uric acid level, the pooled hazard ratio (HR) was 1.51 (95% confidence interval [CI] 1.12-2.02) for all-cause mortality, 1.68 (95% CI 1.28-2.20) for cardiovascular mortality, 1.31 (95% CI 1.10-1.55) for CAD, and 1.48 (95% CI 1.28-1.70) for MACEs. However, there was no significant association between elevated uric acid level and incident stroke in hypertensive patients. This meta-analysis indicates that elevated uric acid level is significantly associated with an increased risk of cardiovascular or all-cause mortality, CAD and MACEs in hypertensive patients. Hypertensive patients with highest uric acid level exhibited a tendency for reduced risk of stroke, but the difference is not significant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.