Evidence map›Paper›PMID 33966130›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2022

Semantic memory impairment in dementia: A cross-cultural adaptation study.

Avanthi Paplikar, V P Vandana, Shailaja Mekala, K J Darshini, Faheem Arshad, Gowri K Iyer, Rajamohan Kandukuri, Gollahalli Divyaraj, Feba Varghese, Subhash Kaul and 2 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06218732 (Understanding Participation Habits), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06218732 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Understanding Participation Habits: An Observational Investigation Within Semantic Dementia Clinical Trials

TypeobservationalSponsorPower Life Sciences Inc.Ran2025 to 2027Enrolled500ConditionsSemantic Dementia
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Language disorders in understudied languages: Opening editorial.Cortex; a journal devoted to the study of the nervous system and behavior · 2025
    Article
  3. Gaps in clinical research in frontotemporal dementia: A call for diversity and disparities-focused research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Avanthi PaplikarDepartment of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Lakkasandra, Bengaluru, Karnataka, 560029, India.
V P VandanaDepartment of Speech Pathology and Audiology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Lakkasandra, Bengaluru, Karnataka, 560029, India.
Shailaja MekalaDepartment of Neurology, Nizam's Institute of Medical Sciences (NIMS), Punjgutta, Hyderabad, Telangana, 500082, India.
K J DarshiniDepartment of Speech Pathology and Audiology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Lakkasandra, Bengaluru, Karnataka, 560029, India.
Faheem ArshadDepartment of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Lakkasandra, Bengaluru, Karnataka, 560029, India.
Gowri K IyerDepartment of Neurology, Nizam's Institute of Medical Sciences (NIMS), Punjgutta, Hyderabad, Telangana, 500082, India.
Rajamohan KandukuriDepartment of Neurology, Nizam's Institute of Medical Sciences (NIMS), Punjgutta, Hyderabad, Telangana, 500082, India.
Gollahalli DivyarajDepartment of Neurology, Nizam's Institute of Medical Sciences (NIMS), Punjgutta, Hyderabad, Telangana, 500082, India.
Feba VargheseDepartment of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Lakkasandra, Bengaluru, Karnataka, 560029, India.
Subhash KaulDepartment of Neurology, Nizam's Institute of Medical Sciences (NIMS), Punjgutta, Hyderabad, Telangana, 500082, India.
Karalyn PattersonDepartment of Clinical Neurosciences, University of Cambridge and MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge, CB2 7EF, UK.
Suvarna AlladiDepartment of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Lakkasandra, Bengaluru, Karnataka, 560029, India. alladisuvarna@hotmail.com.ORCID http://orcid.org/0000-0002-0372-9572
Nizam's Institute of Medical Sciences · INNational Institute of Mental Health and Neurosciences · INMRC Cognition and Brain Sciences Unit · GB

Funding

Department of Science and Technology SR/CSI/13/2008
6 · The paper itself

Abstract

backgroundSemantic memory deficits are frequently encountered in dementia and distinct patterns of semantic impairment characterize the subtypes of dementia. Life course and cultural experiences significantly influence semantic memory. Hence, there is a need to assess semantic memory using culturally appropriate tests, to aid accurate diagnosis of dementia and facilitate cross-cultural collaborative research.

aimsIn this prospective study, we adapted and validated the Cambridge Semantic Memory (CSM) test battery to the Indian cultural context and studied the patterns of semantic memory impairment across dementia subtypes.

methodsThe CSM battery was modified using standard methods and by incorporating culturally appropriate changes and new semantic categories relevant to India. The adapted Indian Semantic Memory (ISM) test battery was administered to a cohort of 121 subjects, consisting of controls and dementia: Alzheimer's disease (AD), progressive non-fluent aphasia (PNFA), semantic dementia (SD), and behavioral variant fronto-temporal dementia (BvFTD). Profile of semantic memory performance across groups was examined.

resultsThe ISM battery was found to be a valid measure of semantic memory. The novel semantic categories of gods/religious icons, vegetables, and food items added value to the diagnostic process. Distinct semantic memory profiles in SD, PNFA, AD, and BvFTD were demonstrated.

conclusionsThe cultural adaptation of a semantic memory battery for the Indian context provided sensitive evidence of semantic memory impairment in dementia and its subtypes. The clinical and research application of the ISM battery will enhance diagnostic evaluation that can aid in early and accurate identification of deficits and devising intervention strategies and enable research across cultures.

Indexed as

Alzheimer DiseaseFrontotemporal DementiaCross-Cultural ComparisonHumansMemory DisordersNeuropsychological TestsProspective StudiesSemanticsAdaptationCambridge Semantic BatteryCross-culturalDementia diagnosisIndian Semantic BatterySemantic memory

Identifiers

PMID33966130
OpenAlexW3161343950

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.