Evidence map›Paper›PMID 33965811›Full record

ArticleJournal of the mechanical behavior of biomedical materials2021

Understanding wear behavior of 3D-Printed calcium phosphate-reinforced CoCrMo in biologically relevant media.

Himanshu Sahasrabudhe, Kellen D Traxel, Amit Bandyopadhyay

Abstract read
In one paragraph

Article in Journal of the mechanical behavior of biomedical materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Graphene and its Derivatives for Bone Tissue Engineering:Frontiers in bioengineering and biotechnology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Himanshu SahasrabudheW. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, 99164, USA.
Kellen D TraxelW. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, 99164, USA.
Amit BandyopadhyayW. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, 99164, USA. Electronic address: amitband@wsu.edu.

Funding

3D Printed Surface Modified Porous Metal Coatings for Load-Bearing ImplantsR01AR067306 · NIAMS · WASHINGTON STATE UNIVERSITY · PI BANDYOPADHYAY, AMIT · 2015 to 2019
$1.8M
NIAMS NIH HHS R01 AR067306
6 · The paper itself

Abstract

Recent advances in the processing of wear-resistant calcium-phosphate reinforced CoCrMo composites for articulating surface applications has necessitated further investigation of performance in biological conditions relevant to patient applications. To this end, CoCrMo composites containing calcium phosphate in the form of hydroxyapatite (HA) were manufactured to study the influence of the reinforcing phase on the tribofilm formation in biologically-relevant conditions. The CoCrMo-HA composites were processed using a laser engineered net shaping (LENS™) additive manufacturing (AM) system with three distinctive compositions: CoCrMo-0%HA, CoCrMo-1%HA, and CoCrMo-3%HA. Extensive wear testing of the CoCrMo-HA composites was carried out in DMEM (cell media) and DMEM + Hyaluronic acid (found naturally in synovial fluid). Wear tests were performed at loads ranging from 5N to 20N, and wear media was measured post-test using ICP-MS techniques to release Co and Cr ions. During testing, all coefficients of friction remained in the 0.15-0.25 range, which was lower than the previously reported 0.50-0.75 range in DI water, indicating that the DMEM + hyaluronic acid media plays a significant role in reducing frictional contact. At loads higher than 15N, the HA-tribofilm exhibited a breakdown resulting in higher wear rates but still lower overall ion release than the CoCrMo control composition. Our results indicate that CoCrMo alloys with HA addition can significantly reduce wear rates and ion release even in the presence of naturally-occurring synovial-fluid friction-reducing media.

Indexed as

AlloysCalcium PhosphatesFrictionHumansIonsPrinting, Three-DimensionalAlloysCalcium PhosphatesIonsCobalt-chromium-molybdenumHydroxyapatiteLaser additive manufacturingTribofilmWear

Identifiers

PMID33965811
PMCPMC8205995

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.