Evidence map›Paper›PMID 33965738›Full record

ArticleClinical biomechanics (Bristol, Avon)2021

Association of toe-extension movement pattern magnitude and variability during three functional tasks with diabetic foot complications.

Jennifer A Zellers, Hana J Bernhardson, Hyo-Jung Jeong, Paul K Commean, Ling Chen, Michael J Mueller, Mary K Hastings

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Clinical biomechanics (Bristol, Avon), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02616263 (Muscle, Joint and Movement Deterioration Contributing to Neuropathic Forefoot Deformity), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02616263 nacompletednot on this map

Muscle, Joint and Movement Deterioration Contributing to Neuropathic Forefoot Deformity

TypeinterventionalSponsorWashington University School of MedicineRan2016 to 2021Enrolled60ConditionsDiabetes Mellitus (DM)ArmsFoot exercise, Shoulder exercise
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jennifer A ZellersProgram in Physical Therapy, Washington University School of Medicine in St. Louis, 4444 Forest Park Ave, St. Louis, MO 63108, USA. Electronic address: jzellers@wustl.edu.
Hana J BernhardsonProgram in Physical Therapy, Washington University School of Medicine in St. Louis, 4444 Forest Park Ave, St. Louis, MO 63108, USA. Electronic address: hana.bernhardson@wustl.edu.
Hyo-Jung JeongProgram in Physical Therapy, Washington University School of Medicine in St. Louis, 4444 Forest Park Ave, St. Louis, MO 63108, USA. Electronic address: jeong.h@wustl.edu.
Paul K CommeanMallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, 4525 Scott Ave, St. Louis, MO 63110, USA. Electronic address: commeanp@wustl.edu.
Ling ChenWashington University School of Medicine in St. Louis, Division of Biostatistics, 660. South Euclid Ave., St. Louis, MO 63110, USA. Electronic address: lingchen@wustl.edu.
Michael J MuellerProgram in Physical Therapy, Washington University School of Medicine in St. Louis, 4444 Forest Park Ave, St. Louis, MO 63108, USA. Electronic address: muellerm@wustl.edu.
Mary K HastingsProgram in Physical Therapy, Washington University School of Medicine in St. Louis, 4444 Forest Park Ave, St. Louis, MO 63108, USA. Electronic address: hastingsmk@wustl.edu.
Washington University in St. Louis · USMallinckrodt (United States) · US

Funding

MUSCLE, JOINT AND MOVEMENT DETERIORATION CONTRIBUTING TO NEUROPATHIC FOREFOOT DEFORMITYR01DK107809 · NIDDK · WASHINGTON UNIVERSITY · PI MARY K HASTINGS · 2016 to 2026
$4.3M
DOCTORAL TRAINING PROGRAM IN MOVEMENT SCIENCET32HD007434 · NICHD · WASHINGTON UNIVERSITY · PI Michael D Harris, Catherine Lang · 1993 to 2026
$4.2M
Diabetes-related Tendon Changes: Integrating Ex Vivo and In Vivo ApproachesF32DK123916 · NIDDK · WASHINGTON UNIVERSITY · PI ZELLERS, JENNIFER · 2019 to 2020
$127k
NICHD NIH HHS T32 HD007434NIDDK NIH HHS F32 DK123916NIDDK NIH HHS R01 DK107809
6 · The paper itself

Abstract

backgroundA toe-extension movement pattern may contribute to metatarsophalangeal joint deformity and ulceration in people with diabetes. We sought to quantify the relationship between toe extension magnitude and variability during three functional tasks (ankle range of motion, sit to stand, walking) with metatarsophalangeal joint deformity, and identify potential mechanisms associated with a toe-extension movement pattern.

methodsIndividuals with diabetes and peripheral neuropathy were included (n = 60). Metatarsophalangeal joint deformity was assessed using computed tomography (CT). Toe-extension movement was quantified using 3-dimensional motion capture. Linear regression was used to investigate the role of toe-extension movement pattern on metatarsophalangeal joint deformity. Regression analysis was used to identify mechanisms (neuropathy severity, foot intrinsic muscle deterioration ratio, ankle dorsiflexion range of motion) contributing to toe-extension movement pattern.

findingsToe extension with each functional task as well as the mean and coefficient of variation across all tasks were significantly related to metatarsophalangeal joint deformity (range of correlation coefficients = (-0.386, 0.692), p ≤ 0.001). Ankle dorsiflexion range of motion was associated with mean toe extension across all tasks (r

interpretationGreater magnitude and lower variability of a toe-extension movement pattern was found to be associated with metatarsophalangeal joint deformity. These findings may support clinical assessment and treatment of movement across more than one task.

Indexed as

Diabetes MellitusDiabetic FootMetatarsophalangeal JointFootHumansRange of Motion, ArticularToesAnkleBiomechanicsFootGaitNeuropathyRehabilitation

Identifiers

PMID33965738
PMCPMC8283772
OpenAlexW3157168586

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.