ArticleGenomics2021
Salmonella Typhi acquires diverse plasmids from other Enterobacteriaceae to develop cephalosporin resistance.
Article in Genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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20 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Pooled it
- Presence of globally prominent multidrug-resistant genotypes ofMicrobial genomics · 2026Article
- Determining genotype and antimicrobial resistance of Salmonella Typhi in environmental samples by amplicon sequencing.PLoS neglected tropical diseases · 2025Article
- Antimicrobial susceptibility trends of S. Typhi and S. Paratyphi in a post-COVID-19 pandemic India, from a multicenter surveillance network.Scientific reports · 2025Article
- Quinolone Resistance Genes qnr, aac(6')-Ib-cr, oqxAB, and qepA in Environmental Escherichia coli: Insights into Their Genetic Contexts from Comparative Genomics.Microbial ecology · 2025Article
- Emergence of carbapenem-resistantFrontiers in microbiology · 2025Article
- Azithromycin-resistant mph(A)-positive Salmonella enterica serovar Typhi in the United States.Journal of global antimicrobial resistance · 2024Article
- The dynamics of blaScientific reports · 2024Article
- Trends in antimicrobial resistance amongst Salmonella Typhi in Bangladesh: A 24-year retrospective observational study (1999-2022).PLoS neglected tropical diseases · 2024Observational
- Article
- Gateway to Typhoid Conjugate Vaccine Introduction in India and Beyond-Programmatic Effectiveness of a Public Sector Typhoid Conjugate Vaccine Campaign in Navi Mumbai.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Antibacterial efficacy of indigenous Pakistani honey against extensively drug-resistant clinical isolates of Salmonella enterica serovar Typhi: an alternative option to combat antimicrobial resistance.BMC complementary medicine and therapies · 2023Article
- Molecular Characterization of Extensively Drug ResistantInfection and drug resistance · 2023Article
- Prevalence of Antimicrobial Resistance Genes inTropical medicine and infectious disease · 2022Review
- Changing Paradigms in Antibiotic Resistance inAntibiotics (Basel, Switzerland) · 2022Article
- Circulation of Third-Generation Cephalosporin Resistant Salmonella Typhi in Mumbai, India.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Antimicrobial Resistance: The 'Other' Pandemic! : Based on 9th Dr. I. C. Verma Excellence Award for Young Pediatricians Delivered as Oration on 19th Sept. 2021.Indian journal of pediatrics · 2022Review
- The Spread of Antibiotic Resistance Genes In Vivo Model.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022Review
- Genomic Epidemiology and Antimicrobial Resistance Mechanisms of Imported Typhoid in Australia.Antimicrobial agents and chemotherapy · 2021Article
- Coriander bornePathogens and global healthArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent reports have established the emergence and dissemination of extensively drug resistant (XDR) H58 Salmonella Typhi clone in Pakistan. In India where typhoid fever is endemic, only sporadic cases of ceftriaxone resistant S. Typhi are reported. This study aimed at elucidating the phylogenetic evolutionary framework of ceftriaxone resistant S. Typhi isolates from India to predict their potential dissemination.
methodsFive ceftriaxone resistant S. Typhi isolates from three tertiary care hospitals in India were sequenced on an Ion Torrent Personal Genome Machine (PGM). A core genome single-nucleotide-polymorphism (SNP) based phylogeny of the isolates in comparison to the global collection of MDR and XDR S. Typhi isolates was built. Two of five isolates were additionally sequenced using Oxford Nanopore MinION to completely characterize the plasmid and understand its transmission dynamics within Enterobacteriaceae.
resultsComparative genomic analysis and detailed plasmid characterization indicate that while in Pakistan (4.3.1 lineage I) the XDR trait is associated with bla
conclusionConsidering the selection pressure exerted by the extensive use of ceftriaxone in India, there are potential risks for the occurrence of plasmid transmission events in the predominant H58 lineages. Therefore, continuous monitoring of S. Typhi lineages carrying plasmid-mediated cephalosporin resistant genes is vital not just for India but also globally.
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