ArticleJournal of the American Academy of Child and Adolescent Psychiatry2022
Reward-Related Neural Circuitry in Depressed and Anxious Adolescents: A Human Connectome Project.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed, 61 citations in OpenAlex.
- The role of reward-related brain activity in response to treatment and later depression severity: data from a randomized controlled trial in early adolescents with anxiety disorders.Translational psychiatry · 2025Trial
- The efficacy and cerebral mechanism of intradermal acupuncture for major depressive disorder: a multicenter randomized controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Trial
- Early life experiences, the neural epigenome and affective disorder risk.Nature reviews. Neuroscience · 2026Review
- HARMONY: A large-scale harmonized neuroimaging dataset for research on anxious misery disorders.bioRxiv : the preprint server for biology · 2026Article
- Transdiagnostic divergent neural development of reward anticipation in early adolescents at risk for depression and psychosis.Developmental cognitive neuroscience · 2026Article
- Sex-Specific Associations of Irritability With Subcortical Brain Volumes.Biological psychiatry global open science · 2026Article
- Depression in Chinese adolescents: prevalence, symptoms, risk factors, affected brain, diagnosis, and interventions.Frontiers in psychology · 2026Review
- Immersive metaverse art as a psychological intervention for depression and anxiety: a narrative review and multilevel model integrating engagement, cultural identity, and neurocognitive mechanisms.Frontiers in psychology · 2026Review
- Striatal and hippocampal contributions to value-based learning in adolescence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Neonatal striatal volume is associated with infant anhedonia.Journal of affective disorders · 2026Article
- Artificial intelligence as decision support for adolescent depression and anxiety: a mini review of clinical utility, safety, and implementation.Frontiers in psychiatry · 2026Review
- Reward Motives are Differentially Related to Depression, Anxiety, and ADHD Symptoms in Middle Childhood.International journal of behavioral development · 2025Article
- Behavioral and neural dysfunctions in reward-related cognitive control among adolescents with major depressive disorder.Psychological medicine · 2025Article
- Trait anxiety is associated with reduced reward-related replay at rest.Nature communications · 2025Article
- Understanding cognitive control in depression: the interactive role of emotion, expected efficacy and reward.BMC psychiatry · 2025Article
- Early life stress and altered social behaviors: A perspective across species.Neuroscience research · 2025Review
- Brain functional connectivity predicts depression and anxiety during childhood and adolescence: A connectome-based predictive modeling approach.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Insights into Overlapping Brain Networks for Anxiety and Alcohol Use Disorders.Current topics in behavioral neurosciences · 2025Review
- Psychiatric neuroimaging at a crossroads: Insights from psychiatric genetics.Developmental cognitive neuroscience · 2024Review
- Prospective associations between early adolescent reward functioning and later dimensions of psychopathology.Journal of psychopathology and clinical science · 2024Article
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Authors and funding
15 authors at 9 institutions in 1 country.
Funding
Abstract
objectiveAlthough depression and anxiety often have distinct etiologies, they frequently co-occur in adolescence. Recent initiatives have underscored the importance of developing new ways of classifying mental illness based on underlying neural dimensions that cut across traditional diagnostic boundaries. Accordingly, the aim of the study was to clarify reward-related neural circuitry that may characterize depressed-anxious youth.
methodThe Boston Adolescent Neuroimaging of Depression and Anxiety Human Connectome Project tested group differences regarding subcortical volume and nucleus accumbens activation during an incentive processing task among 14- to 17-year-old adolescents presenting with a primary depressive and/or anxiety disorder (n = 129) or no lifetime history of mental disorders (n = 64). In addition, multimodal modeling examined predictors of depression and anxiety symptom change over a 6-month follow-up period.
resultsOur findings highlighted considerable convergence. Relative to healthy youth, depressed-anxious adolescents exhibited reduced nucleus accumbens volume and activation following reward receipt. These findings remained when removing all medicated participants (∼59% of depressed-anxious youth). Subgroup analyses comparing anxious-only, depressed-anxious, and healthy youth also were largely consistent. Multimodal modeling showed that only structural alterations predicted depressive symptoms over time.
conclusionMultimodal findings highlight alterations within nucleus accumbens structure and function that characterize depressed-anxious adolescents. In the current hypothesis-driven analyses, however, only reduced nucleus accumbens volume predicted depressive symptoms over time. An important next step will be to clarify why structural alterations have an impact on reward-related processes and associated symptoms.
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