Evidence map›Paper›PMID 33965419›Full record

ArticleChemistry and physics of lipids2021

A spectroscopic study of the composition and conformation of cholesteryl and wax esters purified from meibum.

Anthony Ewurum, Akhila Ankem, Georgi Georgiev, Douglas Borchman

Open access · hybridAbstract read
In one paragraph

Article in Chemistry and physics of lipids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Diurnal Variation of Tear and Meibum Lipids in Healthy Subjects.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Article
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  8. In Vitro Inhibition of Evaporation with Perfluorohexyloctane, an Eye Drop for Dry Eye Disease.Current therapeutic research, clinical and experimental · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Anthony EwurumDepartment of Chemistry, University of Louisville, Louisville, KY, USA.
Akhila AnkemDepartment of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY, USA.
Georgi GeorgieviBB - Institute for Bioengineering and Biosciences, Interdisciplinary Complex, IST, University of Lisbon, 1649-004, Lisbon, Portugal.
Douglas BorchmanDepartment of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY, USA. Electronic address: Borchman@louisville.edu.
University of Louisville · USUniversity of Lisbon · PT

Funding

Tear Film Lipid Compositional, Structural, Functional, Relationships, and Dry EyeR01EY026180 · NEI · UNIVERSITY OF LOUISVILLE · PI BORCHMAN, DOUGLAS · 2016 to 2020
$1.4M
NEI NIH HHS R01 EY026180
6 · The paper itself

Abstract

Elucidating wax ester (WE) and cholesteryl ester (CE) compositional, structural and functional relationships is key to our understanding of how these lipids are involved in natural and pathological processes. Little is known about how CE and WE interact with one another. The focus of the present study is to bridge this gap of knowledge. CE and WE were collected from human meibum as a source of esters with complex hydrocarbon chains. MgO column chromatography was used to separate WE and CE. The esters were characterized using

Indexed as

CholesterolCrystallizationEstersHumansHydrocarbonsMagnetic Resonance SpectroscopyMolecular ConformationPhase TransitionSpectroscopy, Fourier Transform InfraredTearsWaxesCholesterolEstersHydrocarbonsWaxesCholesteryl esterDry eyeSpectroscopyTear filmWax ester

Identifiers

PMID33965419
PMCPMC8620918
OpenAlexW3160277304

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.