ArticleNeuropharmacology2021
Lateral habenula cannabinoid CB1 receptor involvement in drug-associated impulsive behavior.
Article in Neuropharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Increased encoding of aversive stimuli by lateral habenula neurons during ΔNature communications · 2026Article
- Dissociable roles of dopamine D1 and nicotinic receptors in nicotine-motivated responding and impulsive action in a Go/No-Go self-administration task.bioRxiv : the preprint server for biology · 2026Article
- Differential effects of nAChR modulators on impulsive action in a nicotine self-administration Go/No-Go task in rats.Frontiers in pharmacology · 2026Article
- Personal Growth and Wellbeing: An Iterative Mindset Assessment and Perspective.Behavioral sciences (Basel, Switzerland) · 2025Article
- GPR139, an Ancient Receptor and an Emerging Target for Neuropsychiatric and Behavioral Disorders.Molecular neurobiology · 2025Review
- Effects of Repetitive Mild Traumatic Brain Injury on Corticotropin-Releasing Factor Modulation of Lateral Habenula Excitability and Motivated Behavior.Journal of neurotrauma · 2025Article
- The CB1 receptor: linking impulsivity and substance use disorder.Frontiers in neuroscience · 2025Review
- Basal forebrain-lateral habenula inputs and control of impulsive behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Dysregulation of kappa opioid receptor neuromodulation of lateral habenula synaptic function following a repetitive mild traumatic brain injury.Pharmacology, biochemistry, and behavior · 2024Article
- Effects of Repetitive Mild Traumatic Brain Injury on Corticotropin-Releasing Factor Modulation of Lateral Habenula Excitability and Motivated Behavior.bioRxiv : the preprint server for biology · 2024Article
- The Iterative Mindset Method: a neuroscientific theoretical approach for sustainable behavior change and weight-loss in digital medicine.NPJ digital medicine · 2023Review
- Molecular Alterations of the Endocannabinoid System in Psychiatric Disorders.International journal of molecular sciences · 2022Review
- Article
- Inhibition Within the Lateral Habenula-Implications for Affective Disorders.Frontiers in behavioral neuroscience · 2021Review
- Habenular molecular targets for depression, impulsivity, and addiction.Expert opinion on therapeutic targetsArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Animal and human studies show that cannabis or its derivatives can increase relapse to cocaine seeking following withdrawal. Moreover, cannabis use in humans is associated with impulse control deficits and animal studies implicate endogenous cannabinoids (eCB) in several impulsivity constructs. However, the brain areas where cannabinoids might control impulsivity or cocaine seeking are largely unknown. Here, we assess Lateral Habenula (LHb) involvement on performance in the 5-choice serial reaction time task (5CSRTT) in rats and investigate whether LHb cannabinoid CB1 receptors (CB1R) are involved in these effects. Systemic cocaine increased premature responding, a measure of impulsivity, at a dose (5 mg/kg) that did not alter other measures of task performance. Intra-LHb infusion of the CB1R antagonist AM251 blocked this effect. Systemic injection of the psychoactive constituent of cannabis, Δ
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.