Evidence map›Paper›PMID 33965214›Full record

ArticleTrends in neurosciences2021

Stopping the Clock on Seizures!

Xiaoqin Fu, Judy S Liu, Peijun Li

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in neurosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Xiaoqin FuThe Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Judy S LiuDepartment of Neurology, Brown University, Providence, RI 02903, USA; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02903, USA. Electronic address: judy_liu@brown.edu.
Peijun LiThe Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China. Electronic address: 218004@wzhealth.com.
Wenzhou Medical University · CNBrown University · US

Funding

The Circadian Molecular Clock is a Biomarker for Epilepsy in Focal Cortical DysplasiaR01NS104428 · NINDS · BROWN UNIVERSITY · PI LIU, JUDY SHIH-HWA · 2019 to 2022
$2.2M
NINDS NIH HHS R01 NS104428
6 · The paper itself

Abstract

A recent paper by Zhang et al. shows that REV-ERBα, a negative regulator of the circadian molecular clock, is pro-convulsant through its action on GABA signaling. The findings support the role of the circadian molecular clock in epilepsy and suggest REV-ERBα as a potential therapeutic target for the management of seizures.

Indexed as

Circadian ClocksNuclear Receptor Subfamily 1, Group D, Member 1Circadian RhythmHumansSeizuresSignal TransductionNuclear Receptor Subfamily 1, Group D, Member 1circadian molecular clockepilepsytonic GABA

Identifiers

PMID33965214
OpenAlexW3159519095

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.