ArticleInternational journal of retina and vitreous2021
Human amniotic membrane for the treatment of large and refractory macular holes: a retrospective, multicentric, interventional study.
Article in International journal of retina and vitreous, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04904679 (The Use of Amniotic Membrane or Inverted Internal Limiting Membrane Flap for Large or Refractory Macular Holes), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Use of Amniotic Membrane or Inverted Internal Limiting Membrane Flap for Large or Refractory Macular Holes: a Prospective, Comparative Study Using Microperimetry
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Optimal approaches for managing recurrent macular holes: a comprehensive systematic review and meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Pooled it
- The use of amniotic membrane or inverted internal limiting membrane flap for large or refractory macular holes: a prospective, comparative study using microperimetry.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Trial
- Current Approaches in the Management of Complicated Macular Holes.Turkish journal of ophthalmology · 2026Review
- Surgical Outcomes of Epiretinal Human Amniotic Membrane Transplantation for Refractory Macular Holes.Journal of clinical medicine · 2026Article
- Human amniotic membrane graft with viscodissection and intraoperative OCT for macular hole repair.American journal of ophthalmology case reports · 2025Article
- Anatomical and Functional Outcomes of Human-Amniotic Membrane Graft in Refractory Macular Hole Cases.Vision (Basel, Switzerland) · 2025Article
- Management of traumatic macular hole and retinal detachment using amniotic membrane transplantation: A case report.American journal of ophthalmology case reports · 2025Article
- Outcomes of amniotic membrane transplant for refractory macular hole - an optical coherence tomography and autofluorescence long-term study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Subretinal Amniotic Membrane Transplantation in a Porcine Model of Retinal Hole.Investigative ophthalmology & visual science · 2024Article
- Safety and efficacy of human amniotic membrane plug transplantation in cases of macular hole. A scoping review.International journal of retina and vitreous · 2024Article
- Effect of internal limiting membrane surgical techniques on the idiopathic and refractory management of macular holes: a systematic review and meta-analysis.International journal of retina and vitreous · 2024Review
- Swept Source-Optical Coherence Tomography-Guided Facedown Posturing to Minimize Treatment Burden and Maximize Outcome after Macular Hole Surgery.Journal of clinical medicine · 2023Article
- Surgical classification for large macular hole: based on different surgical techniques results: the CLOSE study group.International journal of retina and vitreous · 2023Article
- Comparison of three techniques of harvesting full-thickness retinal tissue for large or persistent macular holes.Indian journal of ophthalmology · 2022Article
- Internal Limiting Membrane Peeling and Flap Inverting under Air in Large Idiopathic Macular Hole Surgery.Journal of ophthalmology · 2021Article
- Optical Coherence Tomography of a Folded Amniotic Membrane over a Macular Hole.Case reports in ophthalmologyArticle
- A study of post-operative clinico-imaging status and visual outcome after idiopathic macular hole surgery with amniotic membrane plug.Romanian journal of ophthalmologyArticle
- Anatomical, functional outcomes, and complications of human amniotic membrane graft for macular hole: A systematic review.Taiwan journal of ophthalmologyReview
- Sealed Unilateral Full-Thickness Macular Hole with Amniotic Membrane Graft in a Patient with Alport Syndrome: A Case Report.Case reports in ophthalmologyArticle
- OCT Features of the Donor Area in Autologous Retinal Transplant Surgery for Macular Hole.Journal of vitreoretinal diseasesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of the current study is to report the anatomical and functional results of off-label human amniotic membrane graft as primary intervention to repair large to giant macular holes and in reoperations when wide internal limiting membrane peeling was unsuccessful.
methodsRetrospective chart review was carried out in five different centers to identify all cases that had undergone off-label human amniotic membrane graft for the treatment of large or failed macular holes (MH). Data collected included age, gender, other concomitant diagnosis, symptoms duration, lens status, number of previous surgeries, macular hole measurements (minimum and base linear diameters), mean post-operative follow-up (months), and pre- and post-operative best corrected visual acuity (BCVA). Main outcome measures were anatomical MH closure rates and final BCVA (in logMAR). Nonparametric Wilcoxon rank-sum test was used because the data was not normally distributed, a P values < 0.05 were considered statistically significant.
resultsNineteen eyes of 19 patients were identified and included in the study. Mean age was 66.21 ± 14.96 years and predominantly females (84%). All eyes had successfully closed MH with a single intervention with no recurrences during a mean of 9 ± 3.87 months follow-up. The median BCVA in logMAR preoperative was 1.30 ± 0.44 (0.80-2.0), approximately 20/400 on Snellen chart and the median BCVA in logMAR postoperative was 1.0 ± 0.72 (0.4-3.0) approximately 20/200 (p < 0.0001) with median of three lines of visual improvement.
conclusionThe use of human amniotic membrane graft seems to be a viable and effective alternative for the treatment of large and persistent macular holes. However, further larger prospective controlled studies are necessary to confirm our preliminary results of this new surgical technique.
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