ArticleAnnals of general psychiatry2021
Altered fractional amplitude of low-frequency fluctuation in women with premenstrual syndrome via acupuncture at Sanyinjiao (SP6).
Article in Annals of general psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- The efficacy and cerebral mechanism of intradermal acupuncture for major depressive disorder: a multicenter randomized controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Trial
- Cerebral blood flow and functional connectivity immediate changes following intradermal acupuncture in major depressive disorder.Frontiers in neuroscience · 2026Article
- Identifying functional brain abnormalities in migraine and depression comorbidity.Quantitative imaging in medicine and surgery · 2022Article
- Functional Magnetic Resonance Imaging Study of Electroacupuncture Stimulating Uterine Acupoints.Computational and mathematical methods in medicine · 2022Article
- Acupuncture modulates the frequency-specific functional connectivity density in primary dysmenorrhea.Frontiers in neuroscience · 2022Article
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundPremenstrual syndrome (PMS) is a prevalent gynecological disease and is significantly associated with abnormal neural activity. Acupuncture is an effective treatment on PMS in clinical practice. However, few studies have been performed to investigate whether acupuncture might modulate the abnormal neural activity in patients with PMS. Thereby, the aim of the study was to assess alterations of the brain activity induced by acupuncture stimulation in PMS patients.
methodsTwenty PMS patients were enrolled in this study. All patients received a 6-min resting-state functional magnetic resonance imaging (rs-fMRI) scan before and after electro-acupuncturing stimulation (EAS) at Sanyinjiao (SP6) acupoint in the late luteal phase of menstrual. Fractional amplitude of low-frequency fluctuation (fALFF) method was applied to examine the EAS-related brain changes in PMS patients.
resultsCompared with pre-EAS at SP6, increased fALFF value in several brain regions induced by SP6, including brainstem, right thalamus, bilateral insula, right paracentral lobule, bilateral cerebellum, meanwhile, decreased fALFF in the left cuneus, right precuneus, left inferior temporal cortex.
conclusionsOur findings provide imaging evidence to support that SP6-related acupuncture stimulation may modulate the neural activity in patients with PMS. This study may partly interpret the neural mechanisms of acupuncture at SP6 which is used to treat PMS patients in clinical.
trial registrationThe study was registered on http://www.chictr.org.cn . The Clinical Trial Registration Number is ChiCTR-OPC-15005918, registry in 29/01/2015.
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