ArticleRespiratory medicine2021
Association of obesity-related inflammatory pathways with lung function and exercise capacity.
Article in Respiratory medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- Respiratory Function Improvement and Lifespan Extension Following Immunotherapy with NP001 Support the Concept That Amyotrophic Lateral Sclerosis (ALS) Is an Immuno-Neurologic Disease.International journal of molecular sciences · 2025Trial
- Obesity and New-Onset Asthma Risk in Chronic Rhinosinusitis: A Population-Based Cohort Study.Laryngoscope investigative otolaryngology · 2026Article
- Beyond the Threshold: Nonlinear Impact of Body Mass Index on Pulmonary Function in Severe Obesity.Obesity facts · 2026Article
- Obesity and Ventilatory Responses During Exercise in the Fitness Registry and the Importance of Exercise National Database (FRIEND).Scandinavian journal of medicine & science in sports · 2026Article
- Endocrinology and the Lung: Exploring the Bidirectional Axis and Future Directions.Journal of clinical medicine · 2025Article
- Prognostic factors affecting mortality in elderly, low body mass index, and poor performance status groups with lung cancer: analysis of the 2016 Korean Association of Lung Cancer Registry (KALC-R) database.Translational lung cancer research · 2025Article
- Effects of metabolic syndrome and its components on pulmonary function and functional capacity in children and adolescents with obesity.European journal of pediatrics · 2025Article
- Association between body roundness index and lung function among U.S. adults.BMC public health · 2025Article
- Relationship Between Plasma Leptin Levels and Airflow Limitation in the Small and Medium Airways in Young Adults.Journal of clinical medicine · 2025Article
- Molecular and pathophysiological intersections between arterial hypertension, pulmonary inflammation and diabetes mellitus.Frontiers in pharmacology · 2025Review
- Nonlinear Relationship Between Body Mass Index Z-Scores and Lung Function Parameters in Asthmatic Children: A Cross-Sectional Study.Journal of asthma and allergy · 2025Article
- Article
- Risk factors and predictive model for secondary hypoxemia following transthoracic drainage in traumatic pneumothorax.American journal of translational research · 2025Article
- Association Between Visceral Fat and Lung Function Impairment in Overweight and Grade I Obese Women: A Cross-Sectional Study.Advances in respiratory medicine · 2024Article
- Associations of weather and air pollution with objective physical activity and sedentary time before and after bariatric surgery: a secondary analysis of a prospective cohort study.Environmental research communications · 2024Article
- Assessment of Behavioral Risk Factors in Chronic Obstructive Airway Diseases of the Lung Associated with Metabolic Syndrome.Journal of clinical medicine · 2024Article
- The negative association between weight-adjusted-waist index and lung functions: NHANES 2007-2012.PloS one · 2024Article
- The Impact of Metabolic Syndrome Risk Factors on Lung Function Impairment: Cross-Sectional Study.JMIR public health and surveillance · 2023Article
- The Mediating Role of Body Mass Index in the Association Between Age at First Childbirth and Lung Function Among Chinese Postmenopausal Women.Clinical epidemiology · 2023Article
- Reviving the mutual impact of SARS-COV-2 and obesity on patients: From morbidity to mortality.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022Review
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
backgroundObesity has multifactorial effects on lung function and exercise capacity. The contributions of obesity-related inflammatory pathways to alterations in lung function remain unclear. RESEARCH QUESTION: To examine the association of obesity-related inflammatory pathways with pulmonary function, exercise capacity, and pulmonary-specific contributors to exercise intolerance.
methodWe examined 695 patients who underwent cardiopulmonary exercise testing (CPET) with invasive hemodynamic monitoring at Massachusetts General Hospital between December 2006-June 2017. We investigated the association of adiponectin, leptin, resistin, IL-6, CRP, and insulin resistance (HOMA-IR) with pulmonary function and exercise parameters using multivariable linear regression.
resultsObesity-related inflammatory pathways were associated with worse lung function. Specifically, higher CRP, IL-6, and HOMA-IR were associated with lower percent predicted FEV
interpretationOur findings highlight the importance of obesity-related inflammatory pathways including inflammation and insulin resistance on pulmonary spirometry and pulmonary vascular function. Specifically, systemic inflammation as ascertained by CRP, IL-6 and insulin resistance are associated with restrictive pulmonary physiology independent of BMI. In addition, inflammatory markers were associated with lower exercise capacity and pulmonary vascular dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.