Evidence map›Paper›PMID 33964681›Full record

ArticleJournal of psychiatric research2021

Digital phenotyping adherence, feasibility, and tolerability in outpatients with schizophrenia.

Ian M Raugh, Sydney H James, Cristina M Gonzalez, Hannah C Chapman, Alex S Cohen, Brian Kirkpatrick, Gregory P Strauss

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  20. Social network reductions are associated with negative symptoms in schizophrenia.Social psychiatry and psychiatric epidemiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ian M RaughDepartment of Psychology, University of Georgia, Athens, GA, USA.
Sydney H JamesDepartment of Psychology, University of Georgia, Athens, GA, USA.
Cristina M GonzalezDepartment of Psychology, University of Georgia, Athens, GA, USA.
Hannah C ChapmanDepartment of Psychology, University of Georgia, Athens, GA, USA.
Alex S CohenDepartment of Psychology, Louisiana State University, Baton Rouge, LA, USA.
Brian KirkpatrickDepartment of Psychiatry and Behavioral Sciences, University of Nevada, Reno School of Medicine, Reno, NV, USA.
Gregory P StraussDepartment of Psychology, University of Georgia, Athens, GA, USA. Electronic address: gstrauss@uga.edu.

Funding

Modeling Anhedonia in Schizophrenia: A Stochastic Dynamical Systems ApproachR21MH112925 · NIMH · UNIVERSITY OF GEORGIA · PI STRAUSS, GREGORY P · 2017 to 2018
$417k
NIMH NIH HHS R21 MH112925
6 · The paper itself

Abstract

Digital phenotyping has potential for use as an objective and ecologically valid form of symptom assessment in clinical trials for schizophrenia. However, there are critical methodological factors that must be addressed before digital phenotyping can be used for this purpose. The current study evaluated levels of adherence, feasibility, and tolerability for active (i.e., signal and event contingent ecological momentary assessment surveys) and passive (i.e., geolocation, accelerometry, and ambulatory psychophysiology) digital phenotyping methods recorded from smartphone and smartband devices. Participants included outpatients diagnosed with schizophrenia (SZ: n = 54) and demographically matched healthy controls (CN: n = 55), who completed 6 days of digital phenotyping. Adherence was significantly lower in SZ than CN for active recordings, but not markedly different for passive recordings. Some forms of passive recordings had lower adherence (ambulatory psychophysiology) than others (accelerometry and geolocation). Active digital phenotyping adherence was predicted by higher psychosocial functioning, whereas passive digital phenotyping adherence was predicted by education, positive symptoms, negative symptoms, and psychosocial functioning in people with SZ. Both groups found digital phenotyping methods tolerable and feasibility was supported by low frequency of invalid responding, brief survey completion times, and similar impediments to study completion. Digital phenotyping methods can be completed by individuals with SZ with good adherence, feasibility, and tolerability. Recommendations are provided for using digital phenotyping methods in clinical trials for SZ.

Indexed as

SchizophreniaEcological Momentary AssessmentFeasibility StudiesHumansOutpatientsSmartphoneAmbulatory assessmentClinical TrialsEcological momentary assessmentExperience samplingPsychosis

Identifiers

PMID33964681
PMCPMC8192468

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.