R21/Matrix-M: a second malaria vaccine?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

13 citing papers in PubMed.

1. Efficacy and Response of R21/Matrix-M in Malaria Vaccine: A Systematic Review and Meta-Analysis of Clinical Trials.Vaccines · 2026
   Review
2. Whole-sporozoite malaria vaccines: where we are, where we are going.EMBO molecular medicine · 2024
   Review
3. Chemical and biological characterization of vaccine adjuvant QS-21 produced via plant cell culture.iScience · 2024
   Article
4. Malaria & mRNA Vaccines: A Possible Salvation from One of the Most Relevant Infectious Diseases of the Global South.Acta parasitologica · 2023
   Article
5. Structural Optimization of BIPPO Analogs as Potent Antimalarials.Molecules (Basel, Switzerland) · 2023
   Article
6. Current advances in nanodrug delivery systems for malaria prevention and treatment.Discover nano · 2023
   Review
7. A Critical Review on Human Malaria and Schistosomiasis Vaccines: Current State, Recent Advancements, and Developments.Vaccines · 2023
   Review
8. Editorial: Current Status of Two Adjuvanted Malaria Vaccines and the World Health Organization (WHO) Strategy to Eradicate Malaria by 2030.Medical science monitor : international medical journal of experimental and clinical research · 2023
   Article
9. Engineered DNA-encoded monoclonal antibodies targeting Plasmodium falciparum circumsporozoite protein confer single dose protection in a murine malaria challenge model.Scientific reports · 2022
   Article
10. Genetic Diversity and Population Genetic Analysis ofGenes · 2022
    Article
11. Enzymatic and structural characterization of HAD5, an essential phosphomannomutase of malaria-causing parasites.The Journal of biological chemistry · 2022
    Article
12. Dynamical Analysis on a Malaria Model with Relapse Preventive Treatment and Saturated Fumigation.Computational and mathematical methods in medicine · 2022
    Article
13. Immune mechanisms targeting malaria transmission: opportunities for vaccine development.Expert review of vaccines
    Review

Corrections and comments

• Comment on
  Efficacy of a low-dose candidate malaria vaccine, R21 in adjuvant Matrix-M, with seasonal administration to children in Burkina Faso: a randomised controlled trial.2021

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

Indexed as