Evidence map›Paper›PMID 33964171›Full record

ArticleBiotechnology and bioengineering2021

Rapid and low-cost sampling for detection of airborne SARS-CoV-2 in dehumidifier condensate.

Parikshit Moitra, Maha Alafeef, Ketan Dighe, Priyanka Ray, James Chang, Aaron Thole, Benjamin Punshon-Smith, Michael Tolosa, Sai Sathish Ramamurthy, Xudong Ge and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Biotechnology and bioengineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Parikshit MoitraDepartments of Diagnostic Radiology and Nuclear Medicine and Pediatrics, Center for Blood Oxygen Transport and Hemostasis, Health Sciences Research Facility III, University of Maryland Baltimore School of Medicine, Baltimore, Maryland, USA.
Maha AlafeefDepartments of Diagnostic Radiology and Nuclear Medicine and Pediatrics, Center for Blood Oxygen Transport and Hemostasis, Health Sciences Research Facility III, University of Maryland Baltimore School of Medicine, Baltimore, Maryland, USA.
Ketan DigheDepartments of Diagnostic Radiology and Nuclear Medicine and Pediatrics, Center for Blood Oxygen Transport and Hemostasis, Health Sciences Research Facility III, University of Maryland Baltimore School of Medicine, Baltimore, Maryland, USA.
Priyanka RayDepartments of Diagnostic Radiology and Nuclear Medicine and Pediatrics, Center for Blood Oxygen Transport and Hemostasis, Health Sciences Research Facility III, University of Maryland Baltimore School of Medicine, Baltimore, Maryland, USA.
James ChangDepartment of Safety and Environmental Health, University of Maryland Medical Center, Baltimore, Maryland, USA.
Aaron TholeDepartment of Chemical, Biochemical, and Environmental Engineering, University of Maryland Baltimore County, Baltimore, Maryland, USA.
Benjamin Punshon-SmithCenter for Advanced Sensor Technology, University of Maryland Baltimore County, Baltimore, Maryland, USA.
Michael TolosaCenter for Advanced Sensor Technology, University of Maryland Baltimore County, Baltimore, Maryland, USA.
Sai Sathish RamamurthyCenter for Advanced Sensor Technology, University of Maryland Baltimore County, Baltimore, Maryland, USA.ORCID 0000-0001-9957-9259
Xudong GeDepartment of Chemical, Biochemical, and Environmental Engineering, University of Maryland Baltimore County, Baltimore, Maryland, USA.ORCID 0000-0003-1733-398X
Douglas D FreyDepartment of Chemical, Biochemical, and Environmental Engineering, University of Maryland Baltimore County, Baltimore, Maryland, USA.
Dipanjan PanDepartments of Diagnostic Radiology and Nuclear Medicine and Pediatrics, Center for Blood Oxygen Transport and Hemostasis, Health Sciences Research Facility III, University of Maryland Baltimore School of Medicine, Baltimore, Maryland, USA.
Govind RaoDepartment of Chemical, Biochemical, and Environmental Engineering, University of Maryland Baltimore County, Baltimore, Maryland, USA.ORCID 0000-0001-6140-7582
University of Maryland, Baltimore · USUniversity of Maryland, Baltimore County · USSri Sathya Sai Institute of Higher Learning · IN

Funding

A Sensing Platform for Rapid at Home-Test of COVID-19R03EB028026 · NIBIB · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI PAN, DIPANJAN · 2019 to 2020
$300k
NIBIB NIH HHS R03 EB028026
6 · The paper itself

Abstract

Airborne spread of coronavirus disease 2019 (COVID-19) by infectious aerosol is all but certain. However, easily implemented approaches to assess the actual environmental threat are currently unavailable. We present a simple approach with the potential to rapidly provide information about the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the atmosphere at any location. We used a portable dehumidifier as a readily available and affordable tool to collect airborne virus in the condensate. The dehumidifiers were deployed in selected locations of a hospital ward with patients reporting flu-like symptoms which could possibly be due to COVID-19 over three separate periods of one week. Samples were analyzed frequently for both virus envelope protein and SARS-CoV-2 RNA. In several samples across separate deployments, condensate from dehumidifiers tested positive for the presence of SARS-CoV-2 antigens as confirmed using two independent assays. RNA was detected, but not attributable to SARS-CoV-2. We verified the ability of the dehumidifier to rapidly collect aerosolized sodium chloride. Our results point to a facile pool testing method to sample air in any location in the world and assess the presence and concentration of an infectious agent to obtain quantitative risk assessment of exposure, designate zones as "hot spots" and minimize the need for individual testing which may often be time consuming, expensive, and laborious.

Indexed as

RNA, ViralSARS-CoV-2Specimen HandlingCOVID-19HumansRNA, ViralairbornecondensateCOVID-19dehumidifierdetectionSARS-CoV-2

Identifiers

PMID33964171
PMCPMC8239551
OpenAlexW3160871307

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.