ArticleSleep2021
Predicting incident dementia and mild cognitive impairment in older women with nonparametric analysis of circadian activity rhythms in the Study of Osteoporotic Fractures.
Article in Sleep, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- A bibliometric analysis on the health behaviors related to mild cognitive impairment.Frontiers in aging neuroscience · 2024Pooled it
- Characterizing circadian rest-activity rhythm patterns across Alzheimer's disease continuum in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association Between Circadian Rest-Activity Rhythms and Incident Dementia in Older Adults: The Atherosclerosis Risk in Communities Study.Neurology · 2026Article
- Observational
- Article
- Article
- Age-related disturbances in rest-activity rhythms and integrity of the hippocampal network: An exploratory study.Neurobiology of sleep and circadian rhythms · 2025Article
- Five-Year Changes in 24-Hour Sleep-Wake Activity and Dementia Risk in Oldest Old Women.Neurology · 2025Article
- Dose-response associations of device-measured sleep regularity and duration with incident dementia in 82391 UK adults.BMC public health · 2025Article
- Association of Rest-Activity Rhythm and Risk of Developing Dementia or Mild Cognitive Impairment in the Middle-Aged and Older Population: Prospective Cohort Study.JMIR public health and surveillance · 2024Article
- Formulating Treatment to Cure Alzheimer's Dementia: Approach #2.International journal of molecular sciences · 2024Review
- Article
- Approaches for assessing circadian rest-activity patterns using actigraphy in cohort and population-based studies.Current sleep medicine reports · 2023Article
- Article
- Sleep-Related Changes Prior to Cognitive Dysfunction.Current neurology and neuroscience reports · 2023Review
- Circadian disruption and sleep disorders in neurodegeneration.Translational neurodegeneration · 2023Review
- Rest-activity rhythms and cognitive impairment and dementia in older women: Results from the Women's Health Initiative.Journal of the American Geriatrics Society · 2022Article
- Sleep Deficiency in the Elderly.Clinics in chest medicine · 2022Review
- Research advances in the study of sleep disorders, circadian rhythm disturbances and Alzheimer's disease.Frontiers in aging neuroscience · 2022Review
- Rest-activity rhythm characteristics associated with lower cognitive performance and Alzheimer's disease biomarkers in midlife women.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
STUDY
objectivesDisrupted daily rhythms are associated with mild cognitive impairment (MCI) and dementia. The specific nature of how rhythms and cognition are related, however, is unknown. We hypothesized characteristics from a nonparametric estimate of circadian rest-activity rhythm patterns would be associated to the development of MCI or dementia.
methodsWrist actigraphy from 1232 cognitively healthy, community-dwelling women (mean age 82.6 years) from the Study of Osteoporotic Fractures was used to estimate rest-activity patterns, including intradaily variability (IV), interdaily stability (IS), most active 10-hour period (M10), least active 5-hour period (L5), and relative amplitude (RA). Logistic regression examined associations of these predictors with 5-year incidence of MCI or dementia. Models were adjusted for potential confounders.
resultsWomen with earlier sleep/wake times had higher risk of dementia, but not MCI, (early vs. average L5 midpoint: OR, 1.66; 95% CI, 1.08-2.55) as did women with smaller day/night activity differentials (low vs. high RA: OR, 1.96; 95% CI, 1.14-3.35). IV, IS, and M10 were not associated with MCI or dementia.
conclusionThe timing and difference in day/night amplitude, but not variability of activity, may be useful as predictors of dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.