ArticleAngewandte Chemie (International ed. in English)2021
A Synthetic Galectin Mimic.
Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 21 citations in OpenAlex.
- A pH-Responsive Synthetic Receptor for Switchable Binding of Carbohydrates.ChemPlusChem · 2025Article
- Molecular Tweezers for Biomimetic Recognition of Carbohydrates.Chembiochem : a European journal of chemical biology · 2025Review
- Galectin-2 AgglutinatesInternational journal of molecular sciences · 2024Article
- Complexation-driven assembly of imine-linked helical receptors showing adaptive folding and temperature-dependent guest selection.Nature communications · 2024Article
- Development and validation a nomogram prediction model for early diagnosis of bloodstream infections in the intensive care unit.Frontiers in cellular and infection microbiology · 2024Article
- Anion binding properties of a hollow PdL-cage.Chemical communications (Cambridge, England) · 2021Article
- A Synthetic Galectin Mimic.Angewandte Chemie (International ed. in English) · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Galectins are a galactoside specific subclass of carbohydrate binding proteins (lectins) involved in various cellular activities, certain cancers, infections, inflammations, and many other biological processes. The molecular basis for the selectivity of galectins is well-documented and revolves around appropriate interaction complementarity: an aromatic residue for C-H⋅⋅⋅π interactions and polar residues for (charge assisted) hydrogen bonds with the axial hydroxyl group of a galactoside. However, no synthetic mimics are currently available. We now report on the design and synthesis of the first galectin mimic (6), and show that it has a higher than 65-fold preference for n-octyl-β-galactoside (8) over n-octyl-β-glucoside (7) in CD
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.