Evidence map›Paper›PMID 33963983›Full record

ArticleInfection2021

CD4/CD8 ratio in pregnant women with HIV and its association with pregnancy outcome: data from a national study in Italy.

Marco Floridia, Carmela Pinnetti, Giulia Masuelli, Arsenio Spinillo, Valeria M Savasi, Giuseppina Liuzzi, Anna M Degli Antoni, Matilde Sansone, Giovanni Guaraldi, Serena Dalzero and 6 more

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In one paragraph

Article in Infection, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 12 institutions in 1 country.

Marco FloridiaNational Center for Global Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy. marco.floridia@iss.it.ORCID http://orcid.org/0000-0003-3971-0141
Carmela PinnettiI.N.M.I. Lazzaro Spallanzani, Rome, Italy.
Giulia MasuelliDepartment of Obstetrics and Neonatology, Città della Salute e della Scienza Hospital, and University of Turin, Turin, Italy.
Arsenio SpinilloDepartment of Obstetrics and Gynaecology, IRCCS S. Matteo, Pavia, Italy.
Valeria M SavasiDepartment of Obstetrics and Gynaecology, Luigi Sacco Hospital and University of Milan, Milan, Italy.
Giuseppina LiuzziI.N.M.I. Lazzaro Spallanzani, Rome, Italy.
Anna M Degli AntoniDepartment of Infectious Diseases and Hepatology, Azienda Ospedaliera di Parma, Parma, Italy.
Matilde SansoneDepartment of Neurosciences, Reproductive and Dentistry Science, University Federico II, Naples, Italy.
Giovanni GuaraldiDepartment of Medical Specialties, Infectious Diseases Clinic, University of Modena and Reggio Emilia, Modena, Italy.
Serena DalzeroDepartment of Obstetrics and Gynaecology, DMSD San Paolo Hospital Medical School, University of Milan, Milan, Italy.
Gianpaolo MasoInstitute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
Daniela FrancisciClinic of Infectious Diseases, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy.
Gaetana SterrantinoSOD Malattie Infettive e Tropicali, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
Marina RavizzaDepartment of Obstetrics and Gynaecology, DMSD San Paolo Hospital Medical School, University of Milan, Milan, Italy.
Enrica TamburriniDepartment of Infectious Diseases, Catholic University and Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Italian Group on Surveillance of Antiretroviral Treatment in Pregnancy
Agostino Gemelli University Polyclinic · ITUniversity of Perugia · ITUniversity of Milan · ITAzienda Ospedaliero-Universitaria Careggi · ITIRCCS Materno Infantile Burlo Garofolo · ITIstituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · ITIstituto Superiore di Sanità · ITOspedale di Parma · ITUniversity of Modena and Reggio Emilia · ITFederico II University Hospital · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITUniversity of Turin · IT

Funding

Agenzia Italiana del Farmaco, Ministero della Salute H85E08000200005
6 · The paper itself

Abstract

purposeTo evaluate associations between CD4/CD8 ratio and pregnancy outcomes in women with HIV.

methodsWe evaluated, in a national study of pregnant women with HIV receiving antiretroviral treatment (ART), values of CD4/CD8 ratio at entry in pregnancy, changes between first and third trimester, and possible associations with preterm delivery, low birthweight, and HIV-RNA < 50 copies/ml at third trimester in univariate and multivariate analyses.

resultsAmong 934 women, 536 (57.4%) were already on ART at conception. CD4/CD8 ratio (baseline value 0.570) increased significantly between the first and third trimesters, particularly in women who started ART in pregnancy (+ 0.163, vs. + 0.036 in women already on treatment). The rate of CD4/CD8 ratio normalization, defined by achieving a ratio ≥ 1 at the third trimester, was 13.2%. In multivariable analyses, women who entered pregnancy with a CD4/CD8 ratio < 0.3, compared to women with ratio ≥ 1, were almost four-times less likely to have third-trimester HIV-RNA < 50 copies/ml (AOR 0.258, 95%CI 0.111-0.601), and more than twice as likely to have preterm delivery (AOR 2.379, 95%CI 1.082-5.232). For preterm delivery, also a baseline CD4/CD8 ratio between 0.3 and 0.45 was significantly associated with an increased risk (AOR: 3.415, 95%CI 1.690-6.900).

conclusionWe described for the first time independent associations of low CD4/CD8 ratio with preterm delivery and HIV-RNA suppression.

Indexed as

HIV InfectionsPregnancy Complications, InfectiousCD8-Positive T-LymphocytesFemaleHumansInfant, NewbornPregnancyPregnancy OutcomePregnant PeopleViral LoadCD4CD4/CD8 ratioCD8HIV suppressionPregnancyPreterm delivery

Identifiers

PMID33963983
OpenAlexW3158666609

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.