Evidence map›Paper›PMID 33963922›Full record

ArticleHistochemistry and cell biology2021

Neurons expressing the aryl hydrocarbon receptor in the locus coeruleus and island of Calleja major are novel targets of dioxin in the mouse brain.

Eiki Kimura, Masanobu Kohda, Fumihiko Maekawa, Yoshiaki Fujii-Kuriyama, Chiharu Tohyama

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Histochemistry and cell biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Aryl hydrocarbon receptor activation affects nitrergic neuronal survival and delays intestinal motility in mice.Toxicological sciences : an official journal of the Society of Toxicology · 2023
    Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Eiki KimuraLaboratory of Environmental Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. eiki-kimura@umin.ac.jp.ORCID http://orcid.org/0000-0001-7164-8099
Masanobu KohdaLaboratory of Environmental Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Fumihiko MaekawaCenter for Health and Environmental Risk Research, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, 305-8506, Japan.ORCID http://orcid.org/0000-0002-1762-8270
Yoshiaki Fujii-KuriyamaMedical Research Institute, Molecular Epidemiology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
Chiharu TohyamaLaboratory of Environmental Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. tohyama.chiharu@hestic.com.ORCID http://orcid.org/0000-0003-1061-6872
National Institute for Environmental Studies · JPTokyo Medical and Dental University · JPUniversity of Tsukuba · JP

Funding

Japan Society for the Promotion of Science 17K12826Japan Society for the Promotion of Science 19H01152Japan Society for the Promotion of Science JP24221003
6 · The paper itself

Abstract

The aryl hydrocarbon receptor (AhR) acts as a receptor that responds to ligands, including dioxin. The AhR-ligand complex translocates from the cytoplasm into the nucleus to induce gene expression. Because dioxin exposure impairs cognitive and neurobehavioral functions, AhR-expressing neurons need to be identified for elucidation of the dioxin neurotoxicity mechanism. Immunohistochemistry was performed to detect AhR-expressing neurons in the mouse brain and confirm the specificity of the anti-AhR antibody using Ahr

Indexed as

AnimalsBasic Helix-Loop-Helix ProteinsBrainDioxinsFemaleImmunohistochemistryLocus CoeruleusMaleMiceMice, Inbred C57BLMice, KnockoutNeuronsReceptors, Aryl HydrocarbonAhr protein, mouseBasic Helix-Loop-Helix ProteinsDioxinsReceptors, Aryl HydrocarbonAryl hydrocarbon receptorDioxinImmunohistochemistryIsland of Calleja majorLocus coeruleusMouse

Identifiers

PMID33963922
PMCPMC8397641
OpenAlexW3159886137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.