Evidence map›Paper›PMID 33963861›Full record

ArticleNucleic acids research2021

BENZ WS: the Bologna ENZyme Web Server for four-level EC number annotation.

Davide Baldazzi, Castrense Savojardo, Pier Luigi Martelli, Rita Casadio

Abstract read
In one paragraph

Article in Nucleic acids research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Davide BaldazziBiocomputing Group, Department of Pharmacy and Biotechnologies, University of Bologna, Italy.
Castrense SavojardoBiocomputing Group, Department of Pharmacy and Biotechnologies, University of Bologna, Italy.
Pier Luigi MartelliBiocomputing Group, Department of Pharmacy and Biotechnologies, University of Bologna, Italy.ORCID 0000-0002-0274-5669
Rita CasadioBiocomputing Group, Department of Pharmacy and Biotechnologies, University of Bologna, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Bologna ENZyme Web Server (BENZ WS) annotates four-level Enzyme Commission numbers (EC numbers) as defined by the International Union of Biochemistry and Molecular Biology (IUBMB). BENZ WS filters a target sequence with a combined system of Hidden Markov Models, modelling protein sequences annotated with the same molecular function, and Pfams, carrying along conserved protein domains. BENZ returns, when successful, for any enzyme target sequence an associated four-level EC number. Our system can annotate both monofunctional and polyfunctional enzymes, and it can be a valuable resource for sequence functional annotation.

Indexed as

SoftwareEnzymesInternetMarkov ChainsMolecular Sequence AnnotationProtein DomainsSequence AlignmentSequence Analysis, ProteinEnzymes

Identifiers

PMID33963861
PMCPMC8262719

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.