Evidence map›Paper›PMID 33963837›Full record

Observational studyThe journals of gerontology. Series A, Biological sciences and medical sciences2021

Physical Activity, Diet, and Incident Urinary Incontinence in Postmenopausal Women: Women's Health Initiative Observational Study.

Scott R Bauer, Stacey A Kenfield, Mathew Sorensen, Leslee L Subak, Suzanne Phelan, Lisa Rogo Gupta, Bertha Chen, Anne M Suskind, Amy J Park, Cheryl Iglesia and 3 more

Open access · greenAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The journals of gerontology. Series A, Biological sciences and medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 1 country.

Scott R BauerDivision of General Internal Medicine, Department of Medicine, University of California, San Francisco, USA.ORCID 0000-0003-4908-1924
Stacey A KenfieldDepartment of Urology, University of California, San Francisco, USA.
Mathew SorensenDepartment of Urology, University of Washington School of Medicine, Seattle, USA.
Leslee L SubakDepartment of Obstetrics & Gynecology, Stanford University, Menlo Park, California, USA.
Suzanne PhelanDepartment of Kinesiology & Public Health, California Polytechnic State University, San Luis Obispo, USA.
Lisa Rogo GuptaDepartment of Obstetrics & Gynecology, Stanford University, Menlo Park, California, USA.
Bertha ChenDepartment of Obstetrics & Gynecology, Stanford University, Menlo Park, California, USA.
Anne M SuskindDepartment of Urology, University of California, San Francisco, USA.
Amy J ParkDepartment of Obstetrics & Gynecology, Georgetown University School of Medicine, Washington, District of Columbia, USA.
Cheryl IglesiaMedStar Health, Columbia, Maryland, USA.
Margery GassUniversity of Cincinnati, Ohio, USA.
Chancellor HohenseeFred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Benjamin N BreyerDepartment of Urology, University of California, San Francisco, USA.
Menlo School · USUniversity of California, San Francisco · USCalifornia Polytechnic State University · USFred Hutch Cancer Center · USGeorgetown University · USMedStar Health · USSan Francisco VA Medical Center · USUniversity of Cincinnati · USUniversity of Washington · US

Funding

VARC CoreP30AG044281 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alexander Keliimoeanu Smith · 2013 to 2026
$19.9M
UCSF-Kaiser Urological Epidemiology Research Career Development ProgramK12DK111028 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, ALISON · 2016 to 2025
$5.3M
Longitudinal Associations Between Frailty and Lower Urinary Tract Symptoms in Older MenR03AG067937 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI BAUER, SCOTT RYAN · 2020 to 2021
$307k
NHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNIA NIH HHS 1R03AG067937NIA NIH HHS P30 AG044281NIA NIH HHS R03 AG067937NIDDK NIH HHS 1K12DK111028NIDDK NIH HHS K12 DK111028
6 · The paper itself

Abstract

backgroundPhysical activity and macronutrient intake, important contributors to energy balance, may be independently associated with female urinary incontinence (UI).

methodsWe evaluated the association of baseline self-reported physical activity and macronutrient intake, via food frequency questionnaire, with incident UI subtypes after 3 years among 19 741 postmenopausal women in the Women's Health Initiative Observational Study. Odds ratios (ORs) for incident urgency, stress, and mixed UI were calculated using multivariable logistic regression.

resultsWomen who reported total physical activity (metabolic equivalent task [MET]-hours/week) ≥30 versus <0.1 were 16% less likely to develop urgency UI (OR = 0.84; 95% CI 0.70, 1.00) and 34% less likely for mixed UI (OR = 0.66; 95% CI 0.46, 0.95), although linear trends were no longer statistically significant after adjusting for baseline weight and weight change (p trend = .15 and .16, respectively). The association between physical activity and incident stress UI was less consistent. Higher uncalibrated protein intake was associated with increased odds of incident urgency UI (≥19.4% vs <14.1% of energy intake OR = 1.14; 95% CI 0.99, 1.30; p trend = .02), while CIs were wide and included 1.0 for calibrated protein intake. Other macronutrients were not associated with urgency UI and macronutrient intake was not associated with incident stress or mixed UI (p trend > .05 for all).

conclusionsAmong postmenopausal women, higher physical activity was associated with lower risk of incident urgency and mixed UI, but not stress UI, independent of baseline weight and weight change. Higher protein intake was associated with increased risk of urgency UI, but no associations were observed between other macronutrient and UI subtypes.

Indexed as

DietExercisePostmenopauseAgedEnergy IntakeFemaleHumansIncidenceMiddle AgedProspective StudiesSelf ReportSurveys and QuestionnairesUrinary IncontinenceCarbohydratesDietary fatDietary proteinExerciseMacronutrientsUrology

Identifiers

PMID33963837
PMCPMC8555422
OpenAlexW3157844793

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.