ArticleAdvanced healthcare materials2021
3D Interrelationship between Osteocyte Network and Forming Mineral during Human Bone Remodeling.
Article in Advanced healthcare materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 64 citations in OpenAlex.
- The coprecipitation-functionalized 3D-printed GM/PDA/PRF hydrogel for infected bone regeneration via synergistic photothermal antibacterial and osteogenic activity.Materials today. Bio · 2026Article
- Low Bone Turnover and Decreased Bone Matrix Mineralization at Diagnosis in Children with Acute Lymphoblastic Leukemia.Calcified tissue international · 2026Article
- Nano-scale evidence for osteocyte network integration across bone remodeling interfaces in human bone revealed by synchrotron nanoCT.Materials today. Bio · 2026Article
- Subclinically low BMD in young men is associated with compromised bone microarchitecture and lower lean mass.Journal of the Endocrine Society · 2026Article
- Electron and focused ion beam microscopy of fossilized Albertosaurus sarcophagus (Dinosauria: Theropoda) bone reveals nano to microscale features.Scientific reports · 2026Article
- Rethinking osteocyte modelsFrontiers in bioengineering and biotechnology · 2026Review
- Gradient mechanical environments modulate intra-osteonal fluid flow: a three-dimensional finite element study.Frontiers in bioengineering and biotechnology · 2026Article
- Molecular drivers of osteogenesis imperfecta: a cellular and extracellular collagen disease.Clinical science (London, England : 1979) · 2025Review
- Demonstration of a novel method to explore osteon tilt in the human femoral cortex.Scientific reports · 2025Article
- Depletion of mmu-miR-185 enhances osteocyte connectivity and suppresses bone fragility through the interaction between ARL8B and RAB5A.Stem cell research & therapy · 2025Article
- Review
- EndoCompass Project: Research Roadmap for Calcium and Bone Endocrinology.Hormone research in paediatrics · 2025Review
- Bone Quality and Mineralization and Effects of Treatment in Osteogenesis Imperfecta.Calcified tissue international · 2024Review
- The Lacunocanalicular Network is Denser in C57BL/6 Compared to BALB/c Mice.Calcified tissue international · 2024Article
- Decoding the mechanical characteristics of the human anterior cruciate ligament entheses through graduated mineralization interfaces.Nature communications · 2024Article
- Bone hierarchical organization through the lens of materials science: Present opportunities and future challenges.Bone reports · 2024Review
- 2D vs. 3D Evaluation of Osteocyte Lacunae - Methodological Approaches, Recommended Parameters, and Challenges: A Narrative Review by the European Calcified Tissue Society (ECTS).Current osteoporosis reports · 2024Review
- A Review of Histological Techniques for Differentiating Human Bone from Animal Bone.Methods and protocols · 2024Review
- Acidic Osteoid Templates the Plywood Structure of Bone Tissue.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Advantages of Using 3D Spheroid Culture Systems in Toxicological and Pharmacological Assessment for Osteogenesis Research.International journal of molecular sciences · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During bone remodeling, osteoblasts are known to deposit unmineralized collagenous tissue (osteoid), which mineralizes after some time lag. Some of the osteoblasts differentiate into osteocytes, forming a cell network within the lacunocanalicular network (LCN) of bone. To get more insight into the potential role of osteocytes in the mineralization process of osteoid, sites of bone formation are three-dimensionally imaged in nine forming human osteons using focused ion beam-scanning electron microscopy (FIB-SEM). In agreement with previous observations, the mineral concentration is found to gradually increase from the central Haversian canal toward pre-existing mineralized bone. Most interestingly, a similar feature is discovered on a length scale more than 100-times smaller, whereby mineral concentration increases from the LCN, leaving around the canaliculi a zone virtually free of mineral, the size of which decreases with progressing mineralization. This suggests that the LCN controls mineral formation but not just by diffusion of mineralization precursors, which would lead to a continuous decrease of mineral concentration from the LCN. The observation is, however, compatible with the codiffusion and reaction of precursors and inhibitors from the LCN into the bone matrix.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.