ArticleESC heart failure2021
Epinephrine administration in venoarterial extracorporeal membrane oxygenation patients is associated with mortality: a retrospective cohort study.
Article in ESC heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Vasoplegia in Cardiac Surgery and Mechanical Circulatory Support: From Cardiopulmonary Bypass to Advanced Circulatory Support Devices.Journal of cardiovascular development and disease · 2026Review
- Optimizing Drug Therapy in ECMO-Supported Critically Ill Adults: A Narrative Review and Clinical Guide.Pharmacy (Basel, Switzerland) · 2025Review
- Diagnostic values of noradrenaline administered dose, procalcitonin (PCT) and blood lactic acid for septic shock.Journal of medical biochemistry · 2025Article
- Impact of mechanical circulatory support on out-of-hospital cardiac arrest outcomes stratified by vasoactive-inotropic score: A retrospective cohort study.Resuscitation plus · 2024Article
- Clinical characteristics of extracorporeal cardiopulmonary resuscitation in China: a multicenter retrospective study.BMC anesthesiology · 2024Article
- Use of vasopressors and inotropes in ECMO.Intensive care medicine · 2024Article
- Authors' reply: Non-invasive therapeutics to prevent left ventricular distension in venoarterial-ECMO patients: no room for epinephrine!ESC heart failure · 2022Article
- Epinephrine infusion during venoarterial extracorporeal membrane oxygenation support for cardiogenic shock: simply inefficient or deleterious?ESC heart failure · 2022Article
- The ABCDE approach to difficult weaning from venoarterial extracorporeal membrane oxygenation.Critical care (London, England) · 2022Review
- Observational
- Epinephrine administration in venoarterial extracorporeal membrane oxygenation patients is associated with mortality: a retrospective cohort study.ESC heart failure · 2021Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsKnowledge about the impact of epinephrine on the outcome in venoarterial (VA) extracorporeal membrane oxygenation (ECMO) patients is limited, and existing data are conflicting. METHODS AND
resultsWe conducted a retrospective cohort study in a 1500 bed tertiary university hospital. Five hundred and eighty-nine VA-ECMO patients were analysed. The median age was 57 years [47-65], 68% of male. The major indications for ECMO were post-cardiotomy cardiogenic shock (CS) (38%) and medical CS (36%). Two hundred and sixty-two (44.5%) patients received epinephrine alone or associated with another catecholamine while on ECMO. Baseline factors significantly associated with epinephrine administration were younger age, higher sequential organ failure assessment score, cardiac arrest at implantation, and intra-aortic balloon pump support at implantation, whereas medical CS and dobutamine administration were significantly associated with a lower risk of epinephrine administration. Epinephrine administration was independently associated with death [hazard ratio = 1.68 (1.44-2.23); P < 0.01]. A sensitivity analysis with propensity score inverse probability weighting in complete cases confirmed a significant association of epinephrine administration with death [hazard ratio = 1.69 (1.43-2.00); P < 0.001].
conclusionsAmong patients who required VA-ECMO, epinephrine administration was associated with an increased risk for death.
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