Evidence map›Paper›PMID 33963778›Full record

ArticleNMR in biomedicine2021

Renal tubular dilation and fibrosis after unilateral ureter obstruction revealed by relaxometry and spin-lock exchange MRI.

Feng Wang, Tadashi Otsuka, Keiko Takahashi, Chikage Narui, Daniel C Colvin, Raymond C Harris, Takamune Takahashi, John C Gore

Open access · greenAbstract read
In one paragraph

Article in NMR in biomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Biomedical optics express · 2023
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Feng WangVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Tadashi OtsukaDivision of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Keiko TakahashiDivision of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Chikage NaruiDivision of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Daniel C ColvinVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Raymond C HarrisVanderbilt O'Brien Kidney Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Takamune TakahashiVanderbilt O'Brien Kidney Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
John C GoreVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Vanderbilt University Medical Center · USVanderbilt University · US

Funding

The Role of renal macrophages in recovery from renal injuryR01DK095785 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RAYMOND C. HARRIS, Mingzhi Zhang · 2013 to 2026
$6.7M
Vanderbilt O'Brien Kidney Center - Core D - Clinical and Translational CoreP30DK114809 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DE CAESTECKER, MARK P. · 2017 to 2021
$5.9M
Proton Relaxation and Exchange Contrast in MRIR01EB024525 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZU, ZHONGLIANG · 2018 to 2021
$2.0M
Upgrade of a 7T Small Animal MRI/MRS SystemS10OD019993 · OD · VANDERBILT UNIVERSITY · PI GORE, JOHN C · 2015 to 2015
$600k
BLRD VA I01 BX000320NIBIB NIH HHS R01 EB024525NIDDK NIH HHS P30 DK114809NIDDK NIH HHS R01 DK095785NIH HHS S10 OD019993
6 · The paper itself

Abstract

We evaluated the use of quantitative MRI relaxometry, including the dispersion of spin-lock relaxation with different locking fields, for detecting and assessing tubular dilation and fibrosis in a mouse model of unilateral ureter obstruction (UUO). C57BL/6 J and BALB/c mice that exhibit different levels of tubular dilation and renal fibrosis after UUO were subjected to MR imaging at 7 T. Mice were imaged before UUO surgery, and at 5, 10 and 15 days after surgery. We acquired maps of relaxation rates and fit the dispersion of spin-lock relaxation rates R

Indexed as

Magnetic Resonance ImagingSpin LabelsAnimalsDilatationDisease ProgressionFibrosisKidney TubulesMaleMiceMice, Inbred BALB CMice, Inbred C57BLUreteral ObstructionSpin LabelsMRIrelaxationrenal fibrosisspin-lock R1ρ dispersiontubular dilationunilateral ureter obstruction

Identifiers

PMID33963778
PMCPMC10805126
OpenAlexW3159372336

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.