Evidence map›Paper›PMID 33963710›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2021

[Energy metabolism disorder and functional magnetic resonance imaging of the medial prefrontal cortex in mice with chronic unpredictable mild stress].

J Zhang, K Liu, S Zeng, C Chen, Y Deng, L Jing, G Wen

Open access · greenAbstract read
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 64% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

J ZhangMedical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
K LiuDepartment of Medical Imaging, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221006, China.
S ZengMedical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
C ChenDepartment of Spleen and Stomach Diseases, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China.
Y DengSchool of Medical Imaging, Xuzhou Medical University, Xuzhou 221006, China.
L JingOperating Theater, TCM Integrated Hospital of Southern Medical University, Guangzhou 510315, China.
G WenMedical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Southern Medical University · CNXuzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo analyze spontaneous activities and energy metabolism in the medial prefrontal cortex (mPFC) of mice with chronic unpredictable mild stress (CUMS) and explore the correlation of these changes with the mTORC1 signaling pathway.

objectiveNormal C57Bl/6 mice were randomly divided into control group (

objectiveCompared with the control mice, CUMS mice exhibited a distinct depressive phenotype with significantly decreased sucrose preference (

objectiveThe mPFC of CUMS mice shows increased spontaneous activities but lowered productivity efficiency, indicating the presence of energy metabolism disorder in the mPFC, which is related with reduced mTORC1 phosphorylation and can be alleviated by activating the mTORC1 pathway with ketamine.

Indexed as

Antidepressive AgentsDepressionAnimalsDisease Models, AnimalEnergy MetabolismHippocampusMagnetic Resonance ImagingMicePrefrontal CortexStress, PsychologicalAntidepressive Agentschronic unpredictable mild stressenengy metabolismfunctional magnetic resonance imagingmedial prefrontal cortexmTORC1

Identifiers

PMID33963710
PMCPMC8110447
OpenAlexW3159710981

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.