Evidence map›Paper›PMID 33963564›Full record

ArticleThe Journal of physiology2021

Delayed KCNQ1/KCNE1 assembly on the cell surface helps I

Zachary T Wilson, Min Jiang, Jing Geng, Sukhleen Kaur, Samuel W Workman, Jon Hao, Tytus Bernas, Gea-Ny Tseng

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Integrative analysis of KCNQ1 variants reveals molecular mechanisms of type 1 long QT syndrome pathogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Preferential Expression of CaBiomolecules · 2022
    Article
  5. Review
  6. Mechanisms and Regulation of Cardiac CaInternational journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Zachary T WilsonDepartment of Physiology & Biophysics, Virginia Commonwealth University, Richmond, VA, USA.
Min JiangDepartment of Physiology & Biophysics, Virginia Commonwealth University, Richmond, VA, USA.ORCID 0000-0002-3413-6307
Jing GengInstitute of Medicinal biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Sukhleen KaurDepartment of Physiology & Biophysics, Virginia Commonwealth University, Richmond, VA, USA.
Samuel W WorkmanDepartment of Physiology & Biophysics, Virginia Commonwealth University, Richmond, VA, USA.
Jon HaoPoochon Scientific, Frederick, MD, USA.ORCID 0000-0002-5060-2662
Tytus BernasDepartment of Anatomy & Neurobiology, Virginia Commonwealth University, Richmond, VA, USA.ORCID 0000-0003-0841-5940
Gea-Ny TsengDepartment of Physiology & Biophysics, Virginia Commonwealth University, Richmond, VA, USA.ORCID 0000-0003-1803-2556
Virginia Commonwealth University · USChinese Academy of Medical Sciences & Peking Union Medical College · CNFrederick Community College · USRutgers, The State University of New Jersey · US

Funding

VCU Neuroscience Center Core GrantP30NS047463 · NINDS · VIRGINIA COMMONWEALTH UNIVERSITY · PI POVLISHOCK, JOHN T · 2003 to 2013
$5.0M
Sodium Channels and Cardiac ArrhythmiasR01HL094450 · NHLBI · OHIO STATE UNIVERSITY · PI DESCHENES, ISABELLE · 2010 to 2022
$4.0M
Cardiac Ion Channel RegulationR01HL096962 · NHLBI · OHIO STATE UNIVERSITY · PI DESCHENES, ISABELLE, TSENG, GEA-NY · 2010 to 2021
$3.6M
Traffic Control of Cardiac Kv ChannelsR01HL128610 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI TSENG, GEA-NY · 2016 to 2019
$1.5M
NHLBI NIH HHS R01 HL094450NHLBI NIH HHS R01 HL096962NHLBI NIH HHS R01 HL128610NINDS NIH HHS P30 NS047463
6 · The paper itself

Abstract

key pointsIn adult ventricular myocytes, the slow delayed rectifier (I ABSTRACT: Slow delayed rectifier (I

Indexed as

KCNQ1 Potassium ChannelPotassium Channels, Voltage-GatedCell MembraneMyocytes, CardiacProteomicsKCNQ1 Potassium ChannelPotassium Channels, Voltage-Gatedcardiac electrophysiologyprotein traffickingproteomicsrepolarization reserve

Identifiers

PMID33963564
PMCPMC8411300
OpenAlexW3157935172

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.