Evidence map›Paper›PMID 33963521›Full record

ArticleMolecular neurobiology2021

Physical Exercise Training Improves Judgment and Problem-Solving and Modulates Serum Biomarkers in Patients with Alzheimer's Disease.

Joni Marcio de Farias, Natalia Dos Santos Tramontin, Eduarda Valim Pereira, Geiziane Laurindo de Moraes, Beatriz Giusti Furtado, Lariani Tamires Witt Tietbohl, Bárbara Da Costa Pereira, Kellen Ugioni Simon, Alexandre Pastoris Muller

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  9. Exercise to Counteract Alzheimer's Disease: What Do Fluid Biomarkers Say?International journal of molecular sciences · 2024
    Review
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  12. Physical exercise-mediated neuroprotective mechanisms in Parkinson's disease, Alzheimer's disease, and epilepsy.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024
    Review
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  16. Targeted Lipidomics and Inflammation Response to Six Weeks of Sprint Interval Training in Male Adolescents.International journal of environmental research and public health · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Joni Marcio de FariasHealth Promotion Research and Study Group, University of Extremo Sul Catarinense, Criciúma, SC, Brazil.
Natalia Dos Santos TramontinPharmacology Department, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
Eduarda Valim PereiraHealth Promotion Research and Study Group, University of Extremo Sul Catarinense, Criciúma, SC, Brazil.
Geiziane Laurindo de MoraesHealth Promotion Research and Study Group, University of Extremo Sul Catarinense, Criciúma, SC, Brazil.
Beatriz Giusti FurtadoHealth Promotion Research and Study Group, University of Extremo Sul Catarinense, Criciúma, SC, Brazil.
Lariani Tamires Witt TietbohlLaboratory of Biomedicine Translational, University of Extremo Sul Catarinense, Criciúma, SC, 88040900, Brazil.
Bárbara Da Costa PereiraLaboratory of Biomedicine Translational, University of Extremo Sul Catarinense, Criciúma, SC, 88040900, Brazil.
Kellen Ugioni SimonLaboratory of Biomedicine Translational, University of Extremo Sul Catarinense, Criciúma, SC, 88040900, Brazil.
Alexandre Pastoris MullerPharmacology Department, Federal University of Santa Catarina, Florianópolis, SC, Brazil. alexandrep.muller@gmail.com.ORCID http://orcid.org/0000-0002-9961-8614
Universidade do Extremo Sul Catarinense · BRUniversidade Federal de Santa Catarina · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is characterized by progressive impairment of memory, with an etiology involving oxidative stress and inflammation. Exercise training is a safe, efficacious, and economic approach to manage neurodegenerative diseases. In AD, the biomarkers of oxidative damage to lipids, proteins, and DNA are elevated. In the present study, we aimed to evaluate whether exercise is effective in patients with AD by assessing the serum biomarkers associated with the redox status, neurotrophin levels, and inflammatory system. This nonrandomized clinical study (n = 15) involved 22 training sessions performed twice a week (60 min/session) in patients diagnosed with AD. The cognitive and self-awareness tests were performed 48 h before and after the physical training session. In patients with AD, physical training significantly improved the judgment and problem-solving domains of the memory score; however, general mental health, memory, orientation, and home/hobby domains were improved slightly, and the neurotrophin levels remained unaltered. Significantly, the markers of protein integrity also increased following exercise. Furthermore, catalase activity and ROS levels decreased, nitrite levels increased, and interleukin-4 level increased following physical training in patients with AD. Although proinflammatory cytokines remained unaltered, the levels of neuron-specific enolase, a marker of neuronal damage, decreased following exercise training in these patients. In conclusion, physical exercise training could be a safe and effective method for blocking the AD progression and improving the antioxidant capacity and anti-inflammatory system, whereas certain assessed biomarkers could be utilized to monitor AD therapy.

Indexed as

ExerciseAgedAged, 80 and overAlzheimer DiseaseBiomarkersCatalaseCytokinesDisease ProgressionFemaleHumansInterleukin-4JudgmentMiddle AgedNeuropsychological TestsOxidative StressPhosphopyruvate HydrataseBiomarkersCatalaseCytokinesInterleukin-4Phosphopyruvate HydrataseReactive Oxygen SpeciesCatalaseDCFHLearning and memoryNeuroinflammationNeurotrophinsNitriteOxidative stress

Identifiers

PMID33963521
OpenAlexW3157413395

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.