Evidence map›Paper›PMID 33963457›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2021

The impact of gender, age, race/ethnicity, and stage on quality of life in a spectrum of cutaneous lymphomas.

Xochiquetzal U Martinez, Arnab Chowdhury, Tracey Stiller, Joycelynne Palmer, Matthew Loscalzo, Estella Barrios, Farah R Abdulla, Jasmine Zain, Steven T Rosen, Christiane Querfeld

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Observational
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xochiquetzal U MartinezDivision of Dermatology, City of Hope, Duarte, USA.
Arnab ChowdhuryDivision of Biostatistics, City of Hope, Duarte, USA.
Tracey StillerDivision of Biostatistics, City of Hope, Duarte, USA.
Joycelynne PalmerDivision of Biostatistics, City of Hope, Duarte, USA.
Matthew LoscalzoPatient & Family Resource Center, City of Hope, Duarte, USA.
Estella BarriosPatient & Family Resource Center, City of Hope, Duarte, USA.
Farah R AbdullaDivision of Dermatology, City of Hope, Duarte, USA.
Jasmine ZainDepartment of Hematology/Hematopoietic Cell Transplantation, City of Hope, Duarte, USA.
Steven T RosenDepartment of Hematology/Hematopoietic Cell Transplantation, City of Hope, Duarte, USA.
Christiane QuerfeldDivision of Dermatology, City of Hope, Duarte, USA. cquerfeld@coh.org.

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI STANLEY R. HAMILTON · 1985 to 2026
$86.3M
Cutaneous T cell lymphoma: a paradigm for dissecting susceptibility and resistance to checkpoint inhibition therapyR01CA229510 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI QUERFELD, CHRISTIANE · 2019 to 2023
$2.8M
Leukemia and Lymphoma Society 2325-19NCI NIH HHS P30 CA033572NCI NIH HHS R01 CA229510NIH HHS P30CA033572NIH HHS R01 CA229510-01
6 · The paper itself

Abstract

purposeCutaneous lymphomas (CLs) are a group of rare, potentially disfiguring and disabling cancers that can have a significant impact on quality of life (QoL). While previous studies have shown that mycosis fungoides (MF) and Sézary syndrome (SS) impair QoL, the effect of other types of CL on QoL has not been evaluated.

objectiveTo determine the impact of disease on QoL in all CL patients and to assess how QoL between the CL sub-types varies by demographic and clinical factors.

methodsThe Cutaneous Lymphoma Distress Questionnaire (CL-DQ) was used to assess QoL. All CL patients seen in a multidisciplinary CL clinic were screened for eligibility. Questionnaire responses were collected over a 22-month period between 2017 and 2019. A cross-sectional analysis of CL-DQ scores from an initial visit was performed to determine the effect of disease on QoL across CL sub-types and the potential impact of patient demographics, CL sub-type, and type of treatment.

resultsThe study population consisted of 151 patients presenting with distinct types of cutaneous B- and T-cell lymphomas. Notable across the study population were the findings of frustration (44%), worry about progress/spread (43%), itching/pruritus (32%), and embarrassment/shame (28%). QoL was found to be most negatively affected in SS patients, females, younger patients, Black patients, and those with advanced stages of MF/SS.

conclusionsImpairment of QoL due to CL correlates with gender, age, race/ethnicity, and stage of MF/SS. While the negative impact on QoL is most pronounced in SS patients, other CL sub-types also affect QoL and impact psychosocial distress. Our findings highlight the need for QoL assessment in all CL patients and further examination of disparities noted across demographic groups.

Indexed as

Sezary SyndromeSkin NeoplasmsCross-Sectional StudiesEthnicityFemaleHumansQuality of LifeCutaneous lymphomaMycosis fungoidesPsychosocial impactQuality of lifeRacial/ethnic disparitiesSézary syndrome

Identifiers

PMID33963457
PMCPMC8801163

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.