Evidence map›Paper›PMID 33963420›Full record

Trial reportJournal of behavioral medicine2021

Mindfulness-based stress reduction for breast cancer survivors (MBSR(BC)): evaluating mediators of psychological and physical outcomes in a large randomized controlled trial.

Cecile A Lengacher, L Forest Gruss, Kevin E Kip, Richard R Reich, Katterine G Chauca, Manolete S Moscoso, Anisha Joshi, Sara Tinsley, Budhrani Shani, Lakeshia Cousin and 3 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of behavioral medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01177124 (Mindfulness-Based Stress Reduction), which is not on this map. Cited by 18 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 4 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01177124 nacompletednot on this map

Mindfulness-Based Stress Reduction (MBSR) Symptom Cluster Trial for Breast Cancer Survivors

TypeinterventionalSponsorCecile LengacherRan2009 to 2013Enrolled300ConditionsBreast CancerArmsMBSR 6 Weeks Program
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Effect of mindfulness-based therapy on spiritual well-being in breast cancer patients: a randomized controlled study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Trial
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  12. Review
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  15. The efficacy of mindfulness-based stress reductionTranslational cancer research · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Cecile A LengacherUniversity of South Florida College of Nursing, MDC 22, 12901 Bruce B. Downs Blvd., Tampa, FL, 33612-4476, USA. cecilel@usf.edu.ORCID 0000-0003-2700-2367
L Forest GrussUniversity of South Florida College of Nursing, MDC 22, 12901 Bruce B. Downs Blvd., Tampa, FL, 33612-4476, USA.
Kevin E KipUniversity of Pittsburgh Medical Center, Pittsburgh, PA, 15261, USA.
Richard R ReichMoffitt Cancer Center, Tampa, FL, 33612, USA.
Katterine G ChaucaUniversity of South Florida College of Nursing, MDC 22, 12901 Bruce B. Downs Blvd., Tampa, FL, 33612-4476, USA.
Manolete S MoscosoUniversity of South Florida College of Nursing, MDC 22, 12901 Bruce B. Downs Blvd., Tampa, FL, 33612-4476, USA.
Anisha JoshiUniversity of South Florida College of Nursing, MDC 22, 12901 Bruce B. Downs Blvd., Tampa, FL, 33612-4476, USA.
Sara TinsleyMoffitt Cancer Center, Tampa, FL, 33612, USA.
Budhrani ShaniTexas Woman's University, Denton, TX, 76204, USA.
Lakeshia CousinMoffitt Cancer Center, Tampa, FL, 33612, USA.
Carly Paterson KhanPatient-Centered Outcomes Research Institute, Washington, D.C, 20036, USA.
Matthew GoodmanUniversity of Virginia, Charlottesville, VA, 22904, USA.
Jong Y ParkMoffitt Cancer Center, Tampa, FL, 33612, USA.
University of South Florida · USMoffitt Cancer Center · USPatient-Centered Outcomes Research Institute · USTexas Woman's University · USUniversity of Pittsburgh Medical Center · USUniversity of Virginia · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5M
Efficacy of MBSR Treatment of Cognitive Impairment Among Breast Cancer SurvivorsR01CA199160 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI LENGACHER, CECILE A · 2015 to 2019
$2.9M
MBSR Symptom Cluster Trial for Breast Cancer SurvivorsR01CA131080 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI LENGACHER, CECILE A · 2009 to 2013
$2.7M
Development of a Quality of Life Decision-Making Model for Older Patients with Acute Myeloid LeukemiaK23NR018488 · NINR · H. LEE MOFFITT CANCER CTR & RES INST · PI TINSLEY, SARA · 2020 to 2022
$474k
NCI NIH HHS 1R01 CA131080-01A2NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA131080NCI NIH HHS R01 CA199160NINR NIH HHS K23 NR018488
6 · The paper itself

Abstract

MBSR(BC) is known to have a positive impact on psychological and physical symptoms among breast cancer survivors (BCS). The cognitive mechanisms of "how" MBSR(BC) works was addressed in a recent study that found that there was strong consistent evidence that reduced emotional reactivity is a mediator and moderate consistent evidence that mindfulness, rumination, and worry were mediators. The purpose of this study, as part of a larger R01 trial, was to test whether positive effects achieved from the MBSR(BC) program were mediated through changes in increased mindfulness, decreased fear of breast cancer recurrence, and perceived stress. Female BCS > 21 years diagnosed with Stage 0-III breast cancer were randomly assigned to a 6-week MBSR(BC) or a Usual Care (UC)regimen. Potential mediators of 6- and 12-week outcomes were identified by analysis of covariance (ANCOVA), followed by formal mediational analyses of main effects of MBSR(BC) on 6- and 12-week outcomes, including percentage of total effects explained. Among 322 BCS (167 MBSR(BC) and 155 UC), fear of recurrence and perceived stress, but not mindfulness, mediated reductions in anxiety and fatigue at weeks 6 and 12, partially supporting our hypothesis of cognitive mechanisms of MBSR(BC).

trial registrationRegistration Number: NCT01177124 http://www.ClinicalTrials.gov.

Indexed as

Breast NeoplasmsCancer SurvivorsMindfulnessFemaleHumansStress, PsychologicalSurvivorsTreatment OutcomeAnxietyBreast cancer survivorsFatigueFear of recurrenceMindfulness-based stress reductionPerceived stress

Identifiers

PMID33963420
OpenAlexW3159831148

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.