Evidence map›Paper›PMID 33963419›Full record

ReviewAbdominal radiology (New York)2021

SBRT for HCC: Overview of technique and treatment response assessment.

Kimberly L Shampain, Caitlin E Hackett, Sohrab Towfighi, Anum Aslam, William R Masch, Alison C Harris, Silvia D Chang, Kanika Khanna, Vivek Mendiratta, Ahmed M Gabr and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Abdominal radiology (New York), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. A Phase II Study of Optimized Individualized Adaptive Radiotherapy for Hepatocellular Carcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Actual over 3-year survival after stereotactic body radiation therapy in patients with unresectable intrahepatic cholangiocarcinoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Editorial commentary on Indian Journal of Gastroenterology-July-August 2021.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2021
    Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Kimberly L ShampainDepartment of Radiology, University of Michigan, Ann Arbor, MI, USA. kshampai@med.umich.edu.ORCID http://orcid.org/0000-0002-6094-1676
Caitlin E HackettDepartment of Radiology, University of Michigan, Ann Arbor, MI, USA.
Sohrab TowfighiDepartment of Radiology, University of British Columbia, Vancouver, BC, Canada.
Anum AslamDepartment of Radiology, University of Michigan, Ann Arbor, MI, USA.
William R MaschDepartment of Radiology, University of Michigan, Ann Arbor, MI, USA.
Alison C HarrisDepartment of Radiology, University of British Columbia, Vancouver, BC, Canada.
Silvia D ChangDepartment of Radiology, University of British Columbia, Vancouver, BC, Canada.
Kanika KhannaDepartment of Hepatology, Henry Ford Hospital, Detroit, MI, USA.
Vivek MendirattaDepartment of Hepatology, Henry Ford Hospital, Detroit, MI, USA.
Ahmed M GabrDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, USA.
Dawn OwenDepartment of Radiation Oncology, Mayo Clinic Rochester, Rochester, MN, USA.
Mishal Mendiratta-LalaDepartment of Radiology, University of Michigan, Ann Arbor, MI, USA.
University of Michigan · USUniversity of British Columbia · CAHenry Ford Hospital · USMayo Clinic · USUniversity of Virginia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stereotactic body radiation therapy (SBRT) is an emerging locoregional treatment (LRT) modality used in the management of patients with hepatocellular carcinoma (HCC). The decision to treat HCC with LRT is evaluated in a multidisciplinary setting, and the specific LRT chosen depends on the treatment intent, such as bridge-to-transplant, down-staging to transplant, definitive/curative treatment, and/or palliation, as well as underlying patient clinical factors. Accurate assessment of treatment response is necessary in order to guide clinical management in these patients. Patients who undergo LRT need continuous imaging evaluation to assess treatment response and to evaluate for recurrence. Thus, an accurate understanding of expected post-SBRT imaging findings is critical to avoid misinterpreting normal post-treatment changes as local progression or viable tumor. SBRT-treated HCC demonstrates unique imaging findings that differ from HCC treated with other forms of LRT. In particular, SBRT-treated HCC can demonstrate persistent APHE and washout on short-term follow-up imaging. This brief review summarizes current evidence for the use of SBRT for HCC, including patient population, SBRT technique and procedure, tumor response assessment on contrast-enhanced cross-sectional imaging with expected findings, and pitfalls in treatment response evaluation.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsRadiosurgeryHumansNeoplasm Recurrence, LocalRetrospective StudiesTreatment OutcomeComputed tomographyHepatocellular carcinomaMagnetic resonance imagingRadiation therapyStereotactic body radiation therapy

Identifiers

PMID33963419
OpenAlexW3158852656

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.