Evidence map›Paper›PMID 33963292›Full record

SynthesisInternational journal of obesity (2005)2021

Obesity and risk of age-related eye diseases: a systematic review of prospective population-based studies.

Clarissa Ng Yin Ling, Su Chi Lim, Jost B Jonas, Charumathi Sabanayagam

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in International journal of obesity (2005), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 3 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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  10. Association of Body Metrics and Ocular Diseases.Journal of clinical medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

Clarissa Ng Yin LingKing's College London, GKT School of Medical Education, London, UK.ORCID http://orcid.org/0000-0003-0873-5741
Su Chi LimKhoo Tech Puat Hospital, Singapore, Singapore.
Jost B JonasDepartment of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Charumathi SabanayagamSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. charumathi.sabanayagam@seri.com.sg.ORCID http://orcid.org/0000-0002-4042-4719
Heidelberg University · DEKing's College London · GBNational University of Singapore · SGSingapore National Eye Center · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObesity is a public health challenge worldwide. The relationship between obesity and age-related eye diseases including cataract, glaucoma, age-related macular degeneration (AMD) and diabetic retinopathy (DR) have remained elusive. DESIGN AND

methodsWe conducted a systematic review of three electronic databases for longitudinal population-based studies that described associations between measures of obesity including body mass index (BMI), waist-circumference (WC), and waist-to-hip ratio (WHR), and age-related eye diseases.

resultsOur search yielded 1731 articles, of which 14, 10, 16 and 8 articles met our eligibility criteria for cataract, glaucoma, AMD and DR, respectively. BMI-defined obesity was positively associated with incident cataract, incident AMD and incident DR in Western populations, but in Asian populations associations for incident AMD were not significant and associations for incident DR were inverse. WC-defined obesity was associated with incident glaucoma in non-Western populations. WHR-defined obesity but not BMI-defined obesity was associated with the incidence or progression of AMD in two Western studies.

conclusionsOverall, we found strong evidence supporting associations between obesity and age-related eye diseases. Further research on the association of abdominal obesity and effect of weight loss and physical activity on age-related eye diseases is warranted to support clinical and public health recommendations.

Indexed as

Age FactorsBody Mass IndexEye DiseasesHumansIncidenceObesityRisk Factors

Identifiers

PMID33963292
OpenAlexW3157424511

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.