ArticleNature communications2021
Subtelomeric assembly of a multi-gene pathway for antimicrobial defense compounds in cereals.
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43citing papers in PubMed
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43 citing papers in PubMed, 103 citations in OpenAlex.
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- A widespread metabolic gene cluster family in metazoans.Nature chemical biology · 2025Article
- Super-pangenome analyses across 35 accessions of 23 Avena species highlight their complex evolutionary history and extensive genomic diversity.Nature genetics · 2025Article
- High-quality genome of allotetraploid Avena barbata provides insights into the origin and evolution of B subgenome in Avena.Journal of integrative plant biology · 2025Article
- From data to discovery: leveraging big data in plant natural products biosynthesis research.The Plant journal : for cell and molecular biology · 2025Review
- Haplotype-resolved genome ofHorticulture research · 2025Article
- Biosynthesis and functions of triterpenoids in cereals.Journal of advanced research · 2025Review
- Comprehensive mutant chemotyping reveals embedding of a lineage-specific biosynthetic gene cluster in wider plant metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genetic engineering, including genome editing, for enhancing broad-spectrum disease resistance in crops.Plant communications · 2025Review
- Anthranilate at the interface of tryptophan and specialized metabolite biosynthesis.Frontiers in plant science · 2025Review
- Identification of the first plant caffeoyl-quinate esterases inFrontiers in plant science · 2025Article
- Understanding metabolic diversification in plants: branchpoints in the evolution of specialized metabolism.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Advances in Engineering Nucleotide Sugar Metabolism for Natural Product Glycosylation inACS synthetic biology · 2024Review
- Telomere-to-telomere reference genome forHorticulture research · 2024Article
- Complete biosynthesis of the potent vaccine adjuvant QS-21.Nature chemical biology · 2024Article
- Subtelomeric plasticity contributes to gene family expansion in the human parasitic flatworm Schistosoma mansoni.BMC genomics · 2024Article
- Unraveling the specialized metabolic pathways in medicinal plant genomes: a review.Frontiers in plant science · 2024Review
- Genome-wide expansion and reorganization during grass evolution: from 30 Mb chromosomes in rice and Brachypodium to 550 Mb in Avena.BMC plant biology · 2023Article
- Decoupling subgenomes within hybrid lavandin provide new insights into speciation and monoterpenoid diversification of Lavandula.Plant biotechnology journal · 2023Article
Corrections and comments
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Authors and funding
44 authors at 6 institutions in 3 countries.
Yan Li *National Centre for Gene Research, CAS-JIC Centre of Excellence for Plant and Microbial Science (CEPAMS), Centre of Excellence for Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), Shanghai, China.
Aymeric Leveau *John Innes Centre, Norwich Research Park, Norwich, UK.
Qiang Zhao *National Centre for Gene Research, CAS-JIC Centre of Excellence for Plant and Microbial Science (CEPAMS), Centre of Excellence for Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), Shanghai, China.
Qi FengNational Centre for Gene Research, CAS-JIC Centre of Excellence for Plant and Microbial Science (CEPAMS), Centre of Excellence for Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), Shanghai, China.ORCID http://orcid.org/0000-0001-5450-1343
Hengyun LuNational Centre for Gene Research, CAS-JIC Centre of Excellence for Plant and Microbial Science (CEPAMS), Centre of Excellence for Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), Shanghai, China.
Jiashun MiaoNational Centre for Gene Research, CAS-JIC Centre of Excellence for Plant and Microbial Science (CEPAMS), Centre of Excellence for Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), Shanghai, China.
Zheyong XueJohn Innes Centre, Norwich Research Park, Norwich, UK.
Azahara C MartinJohn Innes Centre, Norwich Research Park, Norwich, UK.ORCID http://orcid.org/0000-0002-6087-7491
Eva WegelJohn Innes Centre, Norwich Research Park, Norwich, UK.ORCID http://orcid.org/0000-0002-4803-6868
Jing WangJohn Innes Centre, Norwich Research Park, Norwich, UK.
Anastasia OrmeJohn Innes Centre, Norwich Research Park, Norwich, UK.ORCID http://orcid.org/0000-0003-3576-5241
Maria-Dolores ReyJohn Innes Centre, Norwich Research Park, Norwich, UK.ORCID http://orcid.org/0000-0002-6967-8536
Miroslava KarafiátováInstitute of Experimental Botany of the Czech Academy of Sciences, Centre of the Region Haná for Biotechnological and Agricultural Research, Olomouc, Czech Republic.ORCID http://orcid.org/0000-0003-1177-6472
Jan VránaInstitute of Experimental Botany of the Czech Academy of Sciences, Centre of the Region Haná for Biotechnological and Agricultural Research, Olomouc, Czech Republic.
Burkhard SteuernagelJohn Innes Centre, Norwich Research Park, Norwich, UK.ORCID http://orcid.org/0000-0002-8284-7728
Ryan JoynsonEarlham Institute, Norwich Research Park, Norwich, UK.
Charlotte OwenJohn Innes Centre, Norwich Research Park, Norwich, UK.
James ReedJohn Innes Centre, Norwich Research Park, Norwich, UK.ORCID http://orcid.org/0000-0001-5780-6134
Thomas LouveauJohn Innes Centre, Norwich Research Park, Norwich, UK.
Michael J StephensonJohn Innes Centre, Norwich Research Park, Norwich, UK.
Lei ZhangNational Centre for Gene Research, CAS-JIC Centre of Excellence for Plant and Microbial Science (CEPAMS), Centre of Excellence for Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), Shanghai, China.
Xuehui HuangNational Centre for Gene Research, CAS-JIC Centre of Excellence for Plant and Microbial Science (CEPAMS), Centre of Excellence for Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), Shanghai, China.ORCID http://orcid.org/0000-0003-0529-1532
Tao HuangNational Centre for Gene Research, CAS-JIC Centre of Excellence for Plant and Microbial Science (CEPAMS), Centre of Excellence for Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), Shanghai, China.ORCID http://orcid.org/0000-0002-1337-8403
Danling FanNational Centre for Gene Research, CAS-JIC Centre of Excellence for Plant and Microbial Science (CEPAMS), Centre of Excellence for Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), Shanghai, China.
Congcong ZhouNational Centre for Gene Research, CAS-JIC Centre of Excellence for Plant and Microbial Science (CEPAMS), Centre of Excellence for Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), Shanghai, China.
Qilin TianNational Centre for Gene Research, CAS-JIC Centre of Excellence for Plant and Microbial Science (CEPAMS), Centre of Excellence for Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), Shanghai, China.
Wenjun LiNational Centre for Gene Research, CAS-JIC Centre of Excellence for Plant and Microbial Science (CEPAMS), Centre of Excellence for Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), Shanghai, China.ORCID http://orcid.org/0000-0001-8533-6432
Yiqi LuNational Centre for Gene Research, CAS-JIC Centre of Excellence for Plant and Microbial Science (CEPAMS), Centre of Excellence for Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), Shanghai, China.
Jiaying ChenNational Centre for Gene Research, CAS-JIC Centre of Excellence for Plant and Microbial Science (CEPAMS), Centre of Excellence for Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), Shanghai, China.
Yan ZhaoNational Centre for Gene Research, CAS-JIC Centre of Excellence for Plant and Microbial Science (CEPAMS), Centre of Excellence for Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), Shanghai, China.
Ying LuNational Centre for Gene Research, CAS-JIC Centre of Excellence for Plant and Microbial Science (CEPAMS), Centre of Excellence for Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), Shanghai, China.
Chuanrang ZhuNational Centre for Gene Research, CAS-JIC Centre of Excellence for Plant and Microbial Science (CEPAMS), Centre of Excellence for Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), Shanghai, China.
Zhenhua LiuJoint Center for Single Cell Biology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Guy PolturakJohn Innes Centre, Norwich Research Park, Norwich, UK.
Rebecca CassonJohn Innes Centre, Norwich Research Park, Norwich, UK.ORCID http://orcid.org/0000-0003-1139-3359
Lionel HillJohn Innes Centre, Norwich Research Park, Norwich, UK.
Graham MooreJohn Innes Centre, Norwich Research Park, Norwich, UK.
Rachel MeltonJohn Innes Centre, Norwich Research Park, Norwich, UK.
Neil HallEarlham Institute, Norwich Research Park, Norwich, UK.
Brande B H WulffJohn Innes Centre, Norwich Research Park, Norwich, UK.ORCID http://orcid.org/0000-0003-4044-4346
Jaroslav DoleželInstitute of Experimental Botany of the Czech Academy of Sciences, Centre of the Region Haná for Biotechnological and Agricultural Research, Olomouc, Czech Republic.ORCID http://orcid.org/0000-0002-6263-0492
Tim LangdonInstitute of Biological, Environmental and Rural Sciences, Aberystwyth University, Gogerddan, Aberystwyth, Ceredigion, SY23 3EE, UK.
Bin HanNational Centre for Gene Research, CAS-JIC Centre of Excellence for Plant and Microbial Science (CEPAMS), Centre of Excellence for Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CAS), Shanghai, China. bhan@ncgr.ac.cn.ORCID http://orcid.org/0000-0001-8695-0274
Anne OsbournJohn Innes Centre, Norwich Research Park, Norwich, UK. anne.osbourn@jic.ac.uk.ORCID http://orcid.org/0000-0003-2195-5810
John Innes Centre · GBChinese Academy of Sciences · CNCzech Academy of Sciences, Institute of Experimental Botany · CZNorwich Research Park · GBAberystwyth University · GBShanghai Jiao Tong University · CN
Funding
An integrated pipeline for accelerated plant natural product discoveryU01GM110699 · NIGMS · STANFORD UNIVERSITY · PI SMOLKE, CHRISTINA D · 2015 to 2019
$4.5MBiotechnology and Biological Sciences Research Council BB/H009582/1Biotechnology and Biological Sciences Research Council BB/K005952/1Biotechnology and Biological Sciences Research Council BB/L014130/1Biotechnology and Biological Sciences Research Council BBS/E/J/00000614Biotechnology and Biological Sciences Research Council BBS/E/J/000PR9790NIGMS NIH HHS U01 GM110699
Abstract
Non-random gene organization in eukaryotes plays a significant role in genome evolution. Here, we investigate the origin of a biosynthetic gene cluster for production of defence compounds in oat-the avenacin cluster. We elucidate the structure and organisation of this 12-gene cluster, characterise the last two missing pathway steps, and reconstitute the entire pathway in tobacco by transient expression. We show that the cluster has formed de novo since the divergence of oats in a subtelomeric region of the genome that lacks homology with other grasses, and that gene order is approximately colinear with the biosynthetic pathway. We speculate that the positioning of the late pathway genes furthest away from the telomere may mitigate against a 'self-poisoning' scenario in which toxic intermediates accumulate as a result of telomeric gene deletions. Our investigations reveal a striking example of adaptive evolution underpinned by remarkable genome plasticity.
Indexed as
AvenaDisease ResistanceEdible GrainEvolution, MolecularHigh-Throughput Nucleotide SequencingIn Situ Hybridization, FluorescenceMetabolic Networks and PathwaysMultigene FamilyNicotianaRepetitive Sequences, Nucleic AcidRNA-SeqSaponinsSyntenyTelomereWhole Genome Sequencingavenacin A 1Saponins
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