Evidence map›Paper›PMID 33963081›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Low nitrogen conditions accelerate flowering by modulating the phosphorylation state of FLOWERING BHLH 4 in

Miho Sanagi, Shoki Aoyama, Akio Kubo, Yu Lu, Yasutake Sato, Shogo Ito, Mitsutomo Abe, Nobutaka Mitsuda, Masaru Ohme-Takagi, Takatoshi Kiba and 5 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
15.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 111 citations in OpenAlex.

  1. aBIOTECH · 2026
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  10. Cellular energy sensor SnRK1 suppresses salicylic acid-dependent and -independent defenses and bacterial resistance inProceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 4 countries.

Miho SanagiFaculty of Science, Graduate School of Life Science, Hokkaido University, Sapporo 060-0810, Japan.
Shoki AoyamaFaculty of Science, Graduate School of Life Science, Hokkaido University, Sapporo 060-0810, Japan.
Akio KuboFaculty of Science, Graduate School of Life Science, Hokkaido University, Sapporo 060-0810, Japan.ORCID 0000-0003-3015-0344
Yu LuFaculty of Science, Graduate School of Life Science, Hokkaido University, Sapporo 060-0810, Japan.
Yasutake SatoFaculty of Science, Graduate School of Life Science, Hokkaido University, Sapporo 060-0810, Japan.
Shogo ItoGraduate School of Science, Kyoto University, Kyoto 606-8502, Japan.ORCID 0000-0002-8434-6652
Mitsutomo AbeGraduate School of Arts and Sciences, The University of Tokyo, Tokyo 153-8902, Japan.ORCID 0000-0002-8423-1716
Nobutaka MitsudaBioproduction Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba 305-8566, Japan.ORCID 0000-0001-5689-3678
Masaru Ohme-TakagiGraduate School of Science and Engineering, Saitama University, Saitama 338-0825, Japan.ORCID 0000-0003-2700-4119
Takatoshi KibaGraduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan.
Hirofumi NakagamiProtein Mass Spectrometry Group, Max Planck Institute for Plant Breeding Research, D-50829 Cologne, Germany.ORCID 0000-0003-2569-7062
Filip RollandBiology Department, KU Leuven, 3001 Heverlee-Leuven, Belgium.ORCID 0000-0003-2601-0752
Junji YamaguchiFaculty of Science, Graduate School of Life Science, Hokkaido University, Sapporo 060-0810, Japan.
Takato ImaizumiDepartment of Biology, University of Washington, Seattle, WA 98195-1800 takato@uw.edu t-satou@sci.hokudai.ac.jp.ORCID 0000-0001-9396-4412
Takeo SatoFaculty of Science, Graduate School of Life Science, Hokkaido University, Sapporo 060-0810, Japan; takato@uw.edu t-satou@sci.hokudai.ac.jp.ORCID 0000-0001-6707-0706
Hokkaido University · JPKU Leuven · BEKyoto University · JPMax Planck Institute for Plant Breeding Research · DENagoya University · JPNational Institute of Advanced Industrial Science and Technology · JPSaitama University · JPTokyo University of the Arts · JPUniversity of Washington · US

Funding

Molecular Mechanisms of Seasonal Time MeasurementR01GM079712 · NIGMS · UNIVERSITY OF WASHINGTON · PI IMAIZUMI, TAKATO · 2007 to 2022
$3.5M
NIGMS NIH HHS R01 GM079712
6 · The paper itself

Abstract

Nitrogen (N) is an essential nutrient that affects multiple plant developmental processes, including flowering. As flowering requires resources to develop sink tissues for reproduction, nutrient availability is tightly linked to this process. Low N levels accelerate floral transition; however, the molecular mechanisms underlying this response are not well understood. Here, we identify the FLOWERING BHLH 4 (FBH4) transcription factor as a key regulator of N-responsive flowering in

Indexed as

ArabidopsisArabidopsis ProteinsBasic Helix-Loop-Helix ProteinsCell NucleusDNA-Binding ProteinsFlowersGene Expression Regulation, DevelopmentalGene Expression Regulation, PlantNitrogenPhosphorylationPhotoperiodProtein Serine-Threonine KinasesTime FactorsTranscriptional ActivationTranscription FactorsArabidopsis ProteinsAt3g01090 protein, ArabidopsisBasic Helix-Loop-Helix ProteinsCONSTANS protein, ArabidopsisDNA-Binding ProteinsFT protein, ArabidopsisNitrogenProtein Serine-Threonine KinasesTranscription Factorskinasenitrogen availabilityphosphorylationphotoperiodic floweringtranscription factor

Identifiers

PMID33963081
PMCPMC8126780
OpenAlexW3158174337

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.