ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Temporal Relations between Cortical Network Oscillations and Breathing Frequency during REM Sleep.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 53 citations in OpenAlex.
- Human forebrain neural synchronization and entrainment to breathing during wakefulness, sleep, and external mechanical ventilation.Nature communications · 2026Article
- High-Pass Filtering through Short-Term Synaptic Facilitation Amplifies Low-Frequency Modulation of Bursting Input.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Dynamic Respiration-Neural Coupling in Substantia Nigra across Sleep and Anesthesia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Dynamic brain-heart interaction in sleep characterized by variational phase-amplitude coupling framework.Communications biology · 2025Article
- Global coordination of brain activity by the breathing cycle.Nature reviews. Neuroscience · 2025Review
- Evidence That Respiratory Phase May Modulate Task-Related Neural Representations of Visual Stimuli.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Breathing Modulates Network Activity in Frontal Brain Regions during Anxiety.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Wireless monitoring of respiration with EEG reveals relationships between respiration, behavior, and brain activity in freely moving mice.Journal of neurophysiology · 2024Article
- Memory effects of visual and olfactory landmark information in human wayfinding.Cognitive processing · 2024Article
- Respiration modulates sleep oscillations and memory reactivation in humans.Nature communications · 2023Article
- Interoceptive rhythms in the brain.Nature neuroscience · 2023Review
- The temporal structure of REM sleep shows minute-scale fluctuations across brain and body in mice and humans.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Respiration-entrained brain oscillations in healthy fMRI participants with high anxiety.Scientific reports · 2023Article
- Respiratory entrainment of units in the mouse parietal cortex depends on vigilance state.Pflugers Archiv : European journal of physiology · 2023Article
- Controlling neuronal assemblies: a fundamental function of respiration-related brain oscillations in neuronal networks.Pflugers Archiv : European journal of physiology · 2023Review
- The PROUST hypothesis: the embodiment of olfactory cognition.Animal cognition · 2023Review
- Confounding effects of heart rate, breathing rate, and frontal fNIRS on interoception.Scientific reports · 2022Article
- Active neural coordination of motor behaviors with internal states.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Optogenetic stimulation of pre-Bötzinger complex reveals novel circuit interactions in swallowing-breathing coordination.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nasal breathing generates a rhythmic signal which entrains cortical network oscillations in widespread brain regions on a cycle-to-cycle time scale. It is unknown, however, how respiration and neuronal network activity interact on a larger time scale: are breathing frequency and typical neuronal oscillation patterns correlated? Is there any directionality or temporal relationship? To address these questions, we recorded field potentials from the posterior parietal cortex of mice together with respiration during REM sleep. In this state, the parietal cortex exhibits prominent θ and γ oscillations while behavioral activity is minimal, reducing confounding signals. We found that the instantaneous breathing frequency strongly correlates with the instantaneous frequency and amplitude of both θ and γ oscillations. Cross-correlograms and Granger causality revealed specific directionalities for different rhythms: changes in θ activity precede and Granger-cause changes in breathing frequency, suggesting control by the functional state of the brain. On the other hand, the instantaneous breathing frequency Granger causes changes in γ frequency, suggesting that γ is influenced by a peripheral reafference signal. These findings show that changes in breathing frequency temporally relate to changes in different patterns of rhythmic brain activity. We hypothesize that such temporal relations are mediated by a common central drive likely to be located in the brainstem.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.